African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12487

Short Communication

AntiMtb activity of triterpenoid-rich fractions from Spondias mombin L.

Joseph A.O. Olugbuyiro1*, Jones O. Moody2 and Mark T. Hamann3*
  1Department of Chemistry, Covenant University, P. M. B. 1023 Ota, Nigeria. 2Department of Pharmacognosy, University of Ibadan, Ibadan; Nigeria. 3Department of Pharmacognosy, and National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, U.S.A.
Email: [email protected]

  •  Accepted: 05 February 2009
  •  Published: 04 May 2009

Abstract

Spondias mombin L. used in traditional medicine because of its antimicrobial properties was found to contain cardiac glycosides, flavonoids, tannins, and anthraquinones in the stem bark. Bioassay-directed fractionation of the methanol extract of S. mombin was carried out with VLC and HPLC. Isolates were evaluated for antimtb activity which led to the isolation of a series of potential molecules. A semi pure triterpenoid that demonstrated potency of 92.8% inhibition againstMycobaterium tuberculosis (Mtb) at a concentration of 64 μg/ml was further purified by HPLC.

 

Key words: Spondias mombin, Mycobacterium tuberculosis, triterpenoids.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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