African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12487

Full Length Research Paper

Uropathogens isolated from HIV-infected patients from Limpopo Province, South Africa

B. C. Iweriebor1*, C. L. Obi2, O. Akinyemi3, N. J. Ramalivhana4, T. Hattori5 and A. I. Okoh6
1AIDS Virus Research Laboratory, Department of Microbiology, University of Venda, South Africa. 2Division of Academic Affairs and Research, Walter Sisulu University, Mthata, Eastern Cape, South Africa. 3Department of Statistics, University of Venda, South Africa. 4College of Agriculture and Environmental Sciences, University of South Africa, South Africa. 5Department of Emerging Infectious Diseases, Medical School, Tohoku University, Japan. 6Department of Biochemistry and Microbiology, University of Fort Hare, Alice, South Africa.  
Email: [email protected]

  •  Accepted: 04 June 2012
  •  Published: 07 June 2012

Abstract

The primary aim of this study was to determine the prevalence and antibiotic susceptibility profiles of uropathogens isolated from HIV-infected patients in Limpopo Province, South Africa. One hundred and ninety-five urine samples were obtained from HIV-infected patients between June 2008 and May 2009 and the samples were investigated using standard and conventional microbiological methods. Urinary tract infections (UTIs) were detected in 95 samples. Enterobacter species (37.6%) was the most prevalent uropathogen. Other bacterial isolates included Escherichia coli and Klebsiella species, each constituting 17.9%, Citrobacter species (9.7%), Proteus species (7.4%) and others (11.6%). Resistance to trimethoprim/sulfamethoxazole (SXT) which is used for empiric therapy was above 35%. However, majority of the isolates were susceptible to amikacin, ciprofloxacin and most of the second generation cephalosporins as well as imipenem. Resistance of uropathogens to SXT in Limpopo Province is higher than the recommended IDSA setting and this requires the introduction of an alternative first-line therapy. 

Key words: Antibiotic resistance, HIV, uropathogens, urinary tract infections.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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