African Journal of

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12487

Article in Press

Phytochemical, antioxidant and anti-proliferative activity of Epipremnum aureum

Neha Guptaa, Anju Meshramb, Akanksha Kharea, Nidhi Srivastavac*, Sameer S. Bhagyawanta*

  •  Received: 10 March 2022
  •  Accepted: 09 November 2022
Objective: The study was primarily carried out to assess the phytochemical contents present in the leaf of E. aureum. Herein, biochemical characterization vis-à-vis antioxidant potential and antiproliferative activity on cancer cell lines is experimented too. Methods: Healthy leaves of E. aureum after authentication were evaluated in vitro for phytochemical, antioxidant and antiproliferative activity. Various non-enzymatic methods determining the antioxidants capacity and MTT assay for MCF-7 and HepG2 cancer cell lines was employed. Results: Among the various non-enzymatic variables determined viz. DPPH radicle scavenging (67.4 ± 0.8 µg/ml), ABTS (57.2 ± 2.1 µg/ml), FRAP (51.6 ± 3.4 µg/ml), metal chelating (60.4 ± 1.9 µg/ml), hydrogen peroxide scavenging activities (49.6 ± 2.7 µg/ml), radicle scavenging by DPPH induced better inhibition activity. Aqueous leaf extract depicted better IC50 values for breast cancer cell line MCF-7 (35.1 µg/ml) and for human liver carcinoma cell line HepG-2 (41.2 µg/ml) compared to standard anticancer drug tomixifen (12.8 µg/ml). Conclusion: E. aureum leaves, being an important member species of this family, encloses phytochemicals of therapeutic importance too; effects scavenging of free radicles and terminate proliferation activity of cancerous cells.

Keywords: Cytotoxicity of leaves, Araceae family, MCF-7 cells, HepG2, Epipremnum