African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12487

Full Length Research Paper

Assessment of acute toxicity profile of Lasianthera africana leaf extract in normal rats and its ameliorative effect in alloxan-induced diabetic rats

U. E. Inyang*
  • U. E. Inyang*
  • Department of Food Science and Technology, University of Uyo, Uyo, Akwa Ibom State, Nigeria.
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P. A. Nwafor
  • P. A. Nwafor
  • Department of Pharmacology and Toxicology University of Uyo, Uyo, Akwa Ibom State, Nigeria.
  • Google Scholar
U. N. Asamudo
  • U. N. Asamudo
  • Department of Microbiology University of Uyo, Uyo, Akwa Ibom State, Nigeria.
  • Google Scholar


  •  Received: 11 September 2014
  •  Accepted: 25 March 2015
  •  Published: 15 April 2015

References

Achukwu PUO, Azubike NC, Okwuosa CN, Onu TO (2009). Toxicological study of the aqucous leaf extract of Mucuna flagellipes on albino wister rats. Afr. J. Sci. 10(1):2293-2303.
 
Akah PA, Alemji JA, Salawu OA, Okoye TC, Offiah NV (2009). Effect of Vernonia amygdalina on biochemical and haematological parameters of diabetic rats. Asian J. Med. Sci. 1(3):108-113.
 
Akah PA, Okoli CO, Nwafor SV (2002). Phytotherapy in the management of diabetes mellitus. J. Nat. Rem. 2:1-10.
 
Alarcon-Aguilar FJ, Calzada-Bermajo F, Hernandez-Galicia E, Ruiz-Angeles C, Roman-Ramos R (2005). Acute and chronic hypoglycaemic effect of Ibervillea sonorae root extract – II. J. Ethnopharmacol. 97:447-452.
Crossref
 
Andy IE, Eja ME, Mboto CI (2008). An evaluation of the antimicrobial potency of Lasianthera africana (Beauv) and Heinsia crinata (G. Taylor) on Escherichia coli, salmonella typhi, staphylococcusaureus and candida albicans. Malays. J. Microbiol. 4(1):25-29.
 
Angelis Pereira MC, Carvalho JCT, Lima LM, Caputo LRG, Ferreira LR, Fiorini JE, Baston JK (2003). Toxicity of a sub-chronic treatment with hydroalcoholic crude extract from Solanum grandiflorum (Ruiz Pav) in rats. J. Ethnopharmacol. 89:97-99.
Crossref
 
Antai AB, Ofem OE, Nwosu OJ, Ukafia SO, Iyadi KC, Nia R, Osim EE (2010). Comparative effects of Rothmannia hispida leaves extract and protamine-zinc insulin on alloxan-induced diabetic rats. Afr. J. Biomed. Res. 13:47-54.
 
Bassey ME, Etuk EUI, Ubom R, Obop IE (2006). Chemotaxonomic study of Lasianthera africana (lcacinaceae) in Akwa Ibom State of Nigeria. Nig. J. Bot. 19:99-102.
 
Ebana RU, Essien AI, Ekpo OD (1996). Potential medicinal value of leaves of Lasianthera africana P. Beav. Glob. J. Pure Appl. Sci. 1:2-7.
 
Elizabeth H, Harris MD (2005). Elevated liver function tests in type 2 diabetes. Clin. Diabetes 23:115-119.
Crossref
 
Etukudo I (2003). Ethnobotany conventional and traditional uses of lants. Verdict Press, Uyo. pp. 12-65.
 
Hilaly J, El Israili ZH, Lyoussi B (2004). Acute and chronic toxicological studies of Ajuga iva in experimental animals. J. Ethnopharmacol. 91: 43-50.
Crossref
 
Hutchinson J, Dalziel JM (1973). Flora of West Tropical Africa (2nd edn.), Crown Agents, London, p. 638.
 
Ikewuchi JC, Ikewuchi CC (2012). Hypoglycemic, hypocholesterolemic ocular-protective effect of an aqueous extract of the Rhizomes of Sunsevieria senegambia Baker (Agavaccac) on alloxan-induced diabetic Wister rats. Am. J. Biochem. Mol. Biol. 2:48-66.
Crossref
 
Kennedy GL, Ferenz RL, Burgess BA (1986). Estimation of acute oral toxicity in rats by determination of the approximate lethal dose rather than the LD50. J. Appl. Toxicol. 6:145-148.
Crossref
 
Kesari AN, Gupta RK, Watal G (2005). Hypoglycemic effect of Murraya koenigii on normal and alloxan-diabetic rabbits. J. Ethnopharmacol. 97:247-251.
Crossref
 
Li WL, Zheng HC, Bukuru J, De Kimpe N (2004). Natural medicines used in the traditional Chinese medical system for therapy of diabeties mellitus. J. Ethnopharmacol. 92:1-21.
Crossref
 
Lorke D (1983). A new approach to acute toxicity testing. Arch. Toxicol. 54:275-287.
Crossref
 
Moram GS (2001). Effect of aqueous extracts from some plants on alloxan-diabetic rats. Egypt. J. Hosp. Med. 2:57-69.
 
Mowla A, Alauddin M, Rahman MA, Ahmed K (2009). Antihyperglycaemic effect of Trigonella foe numgraecum (Fenugreek) seed extract in alloxan-induced diabetic rats and its use in diabetes mellitus: A brief qualitative phytochemical and acute toxicity test on the extract. Afr. J. Trad. Cam. 6(3):255-261.
 
Newman DJ, Price CP (1999). Renal function and nitrogen metabolites. In: Burtis CA, Ashwood ER (Eds.). Tietz textbook on clinical chemistry. W. B. Saunders Company, Philadelphia, pp. 1204-1270.
 
NIH Publication (1985). Respect for life. National Institute of Environmental Health Science. Pub. No. 85-23.
 
Nwanjo HU (2007). Studies on the effect of aqueous extract of Phyllanthus niruri on plasma glucose level and some hepatospecific markers in diabetic Wister rats. Int. J. Lab. Med. 2(2):1-18.
 
Rasekh HR, Nasari P, Kamli-Leila M, Hosseinzadeh L (2008). Acute and sub-chronic oral toxicity of Galega officinalis in rats. J. Ethnopharmacol. 116:21-26.
Crossref
 
Rawi SM, Abdel-Moneim A, Ahmed OM (1998). Studies on the effect of garlic oil and the glibenclamide on alloxan-diabetic rats. Egypt J. Zool. 30:211-228.
 
Raza M, Al-Shabanah OA, El-Hadiyah TM, Al-Majed AA (2002). Effect of prolonged vigabatrim treatment on haematological and biochemical parameters in plasma, kidney and liver of Swiss Albino mice. Sci. Pharm. 70:135-145.
 
Rock RC, Walker G, Jennings D (1986). Nitrogen metabolites and renal functions. In: Tietz NW (ed). Textbook of clinical chemistry. W. B. Saunders Company, London, pp. 1254-1316.
 
Sofowora A (1989). Medicinal plants and traditional medicine in Africa. John Wiley and sons Ltd. London. pp. 12-146.
 
Sood R (2006). Textbook of medical laboratory technology. Jaypee Brothers medical Publishers Ltd., New Delhi, pp. 196-210, 598-690.
Crossref
 
Stanely P, Mainzen P, Venugopal PM (2010). Hypoglycaemic and other related actions of Tinospora cordifolia roots in alloxan-induced diabetic rats. J. Ethnopharmacol. 70:9-15.
Crossref
 
Tang L, Wei W, Chen L, Liu S (2006). Effect of berberina on diabetes induced by alloxan and a high-fat/high-cholesterol diet in rats. J. Ethnopharmcol. 108:109-115.
Crossref
 
Teo S, Stirling D, Thomas S, Hoberman A, Kiorpes A, Khetani V (2002). A 90-day oral gavage toxicity of D-methylphenidate and D, L-mathylphenidate in Sprague-Dawley rats. Toxicology 179:183-196.
Crossref
 
Whitehead MW, Hawkes ND, Hainsworth I, Kingham JG (1999). A prospective study of the causes of notably raised aspartate amino-transferase of liver origin. Gut 45:129-133.
Crossref
 
WHO (1980). WHO Expert Committee on Diabetes Mellitus Technical report series. World Health Organization, Geneva.
 
Williams IO, Parker RS, Swanson J (2009). Vitamin A content of South Eastern Nigerian vegetable dishes, their consumption pattern and ontribution to vitamin A requirement. Pak. J. Nutr. 8(7): 1000-1004.
Crossref
 
Wilson NH, Hardisty JF, Hayes JR (2001). Short-term, sub-chronic and chronic toxicity studies. In: A. W. Hayes (ed). Principles and methods of Toxicology. Taylor and Francis, Philadelphia. pp. 917-956.
 
Woodman DD (1996). Assessment of hepatotoxicity. In: GO Evans (ed); Animal clinical chemistry, A Premer for Toxicologists. Taylor and Francis, London, pp. 71-86.