African Journal of

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12400

Full Length Research Paper

Studies on styrene concentration in drinking water and hot beverages in some settings

Naser L. Rezk
  • Naser L. Rezk
  • Clinical Laboratory Sciences Department, College of Applied Medical Sciences, Taibah University, Al-Madinah Al-Munawara, Kingdom of Saudi Arabia.
  • Google Scholar
Saber M. Eweda
  • Saber M. Eweda
  • Clinical Laboratory Sciences Department, College of Applied Medical Sciences, Taibah University, Al-Madinah Al-Munawara, Kingdom of Saudi Arabia.
  • Google Scholar
Salma A. Rezk
  • Salma A. Rezk
  • Pathology Department, School of Medicine, University of North Carolina, Chapel Hill, NC, USA.
  • Google Scholar
Sameh Ahmed
  • Sameh Ahmed
  • Pharmacognosy and Pharmaceutical Chemistry Department, College of Pharmacy, Taibah University, Al-Madinah Al-Munawara, Kingdom of Saudi Arabia.
  • Google Scholar

  •  Received: 17 February 2018
  •  Accepted: 16 May 2018
  •  Published: 20 June 2018


Arnedo-Pena A, Bellido-Blasco J, Villamarin-Vazquez JL, Aranda-Mares JL, Font-Cardona N, Gobba F, Kogevinas M (2003). Acute health effects afteraccidental exposure to styrene from drinking water in Spain. Environmental Health 2(1):6.


Ashton D (2014). A Traveller's Guide to Tap Water. Available online: 

View (accessed on 31 March 2018).


Bourque AJ, Krull IS, Feibush B (1994). Automated HPLC analyses of drugs of abuse via direct injection of biological fluids followed by simultaneous solid-phase; determination of volatile solvents and their metabolites in urine for monitoring occupational exposure. Biomedical Chromatography 8(2):53-62.


Brown A, Lamb C, Brown, M, Neal A (2000). Review of the developmental and reproductive toxicity of styrene. Regulatory Toxicology and Pharmacology 32:228-247.


Cabejskova Z (2016). The Role of Tap Water in Public Health and Hydration. Water UK: London, UK.


Chakroun R, Faidi F, Hedhili A, Charbaji K, Nouaigui H, Laiba MB (2008). Inhalant Abuse Detection and Evaluation in Young Tunisians. Journal of Forensic Sciences 53(1):232-237.


Cohen T, Carlson G, Charnley G, Coggon D, Delzell E, Graham JD (2002). A comprehensive evaluation of the potential health risks associated with occupational and environmental exposure to styrene. Journal of Toxicology and Environmental Health, Part B 5(1-2):1-263.


Food and Drug Administration (FDA) (2003). Total diet study– summary of residues found ordered by pesticides. Market baskets 91-3–991.


Food and Drug Administration (FDA) (2007). Guidance for Industry: Preparation of Premarket Submissions for Food Contact Substances: Chemistry Recommendations. [Internet]. [cited 2017 Sept 5]. Available from: 



Fujii T, Kawabe, S, Horike, T, Taguchi T, Ogata M (1999). Simultaneous determination of the urinary metabolites of toluene, xylene and styrene using high-performance capillary electrophoresis: Comparison with high-performance liquid chromatography. Journal of Chromatography B: Biomedical Sciences and Applications 730(1):41-47.


Inoue O, Seiji K, Suzuki T, Watanabe T, Nakatsuka H, Satoh H, Ikeda M (1991). Simultaneous determination of hippuric acid, o-, m-, and p-methylhippuric acid, phenylglyoxylic acid, and mandelic acid by HPLC Bulletin of Environmental Contamination and Toxicology 47(2):204-210.


IARC-International Agency for Research on Cancer (1994). Some industrial chemicals. 60:323-550.


IARC-International Agency for Research on Cancer (2002). Some traditional herbal medicines, some mycotoxin, naphthalene and styrene. 82:437-550.


Jambeck J R, Geyer R, Wilcox C, Siegler T R, Perryman M, Andrady A, Narayan, Law KL (2015). Plastic waste inputs from land into the ocean. Science 347:768-771.


Kataoka H, Manabe K, Nakase S, Makita (1991). Determination of hippuric acid and o-, m- and p-methylhippuric acids in urine by capillary gas chromatography. Journal of Pharmaceutical and Biomedical Analysis 9(9):699-704.


Khaksar MR, Ghazi-Khansari M (2009). Determination of migration monomer styrene from GPPS (general purpose polystyrene) and HIPS (high impact polystyrene) cups to hot drinks. Toxicology Mechanisms and Methods 19(3):257-261.


Kwon BG, Chung SY, Park SS, Saido K (2018). Qualitative assessment to determine internal and external factors influencing the origin of styrene oligomers pollution by polystyrene plastic in coastal marine environments. Environmental Pollution 234:167-173.


Lian J, McKenna R, Rover MR, Nielsen DR, Wen Z, Jarboe LR (2016). Production of biorenewable styrene: utilization of biomass-derived sugars and insights into toxicity. Journal of Industrial Microbiology and Biotechnology 43:595–604


Maqbool A, Ahmed SB (2007). Leaching of styrene and other aromatic compounds in drinking water from PS bottles. Journal of Environmental Sciences 19:421-426.


Marais AA, Laurens JB (2005). Analysis of urinary biomarkers for exposure to alkyl benzenes by isotope dilution gas chromatography-mass spectrometry. Journal of Separation Science 28(18):2526-2533.


Muratak A, Avakis S, Yokoyama K (1991). Assessment of the peripheral, central and autonomic nervous system function in styrene workers. American Journal of Industrial Medicine 20(6):775-784.


Pacenti M, Dugheri, S, Villanelli F, Bartolucci G, Calamai L, Boccalon P, Arcangeli G, Vecchione F, Alessi P, Kikic I, Cupelli V (2008). Determination of organic acids in urine by solid-phase microextraction and gas chromatography–ion trap tandem mass spectrometry previous 'in sample' derivatization with trimethyloxonium tetrafluoroborate. Biomedical Chromatography 22:1155-1163.


Qin-Bao L, Xue-Chao S, Hong F, Yu-Mei W, Zhi-Wei W (2017). Migration of styrene and ethylbenzene from virgin and recycled expanded polystyrene containers and discrimination of these two kinds of polystyrene by principal component analysis. Food Additives and Contaminants 34(1):126-132.


Saylor A, Prokopy LS, Amberg S (2011). What's wrong with the Tap? Examining Perceptions of Tap Water and Bottled Water at Purdue University. Environmental Management 48(3):588-601.


Sherrington EJ, Routledge PA (2001). The toxicity of styrene monomer. Adverse Drug Reactions and Toxicological Reviews, 20(1):9-35.


US Food and Drug Administration (USFDA) (2001). FDA guidance for industry: bioanalytical method validation. US Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research: Rockville, MD. Available at: 



Varner SL, Breder A (1981). Headspace sampling and gas chromatographic determination of styrene migration from food-contact polystyrene cups into beverage and food simulants. Journal-Association of Official Analytical Chemists, 64(5):1122-1130.


Varner SL, Breder CV, Fazio T (1983). Determination of styrene migration from food-contact polymers into margarine, using Azeotropic distillation and head space gas chromatography. Journal-Association of Official Analytical Chemists 66:1067-1073.


World Health Organization, International Agency for Research on Cancer (WHO and IARC) (1993). Some naturally occurring substances: food items and constituents, heterocyclic aromatic amines and mycotoxins. IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. P 56.


Zhang W, Zhang S, Wang J, Mu J, Wang P, Lin X, Ma D (2017). Microplastic pollution in the surface waters of the Bohai Sea, China. Environmental Pollution 231:541-548.