February 2009

Isolation and preliminary characterization of conophor nut (Tetracarpidium conophorum) lipase

  Lipase in oilseeds helps to hydrolyze the ester bonds of storage triacylglycerols. The crude lipase from the conophor nut (Tetracarpidium conophorum) was isolated and assayed via quantification of the free fatty acids liberated by the hydrolysis of the oilseed triacylglycerols. Optimum pH and temperature for the enzyme activity of the conophor nut lipase was pH 8.0 and at 30°C with substantial lipolysis...

Author(s): Victor N. Enujiugha

February 2009

A study on the combined administration of chloroquine and insulin effect on serum transferases and phosphatases activity during increased dietary fat and calcium consumption

  Previous studies reported on relationship between chloroquine administration, insulin and glucose homeostasis, but the role of dietary fat and the combined effect of the drugs on liver function have not been exploited. The present study was set up to investigate the effect of combined administration of insulin and chloroquine on serum transferase and phosphates activity during increased dietary fat and...

Author(s): Ajani E. O., Salau B. A., Ezima E. N. , Oyefuga O. H. and Osineye P. O.

February 2009

Antinociceptive properties of Trigonella foenumgreacum seeds extracts

  Trigonella foenum-graecum L. (Leguminosae), known in Morocco as “Helba”, is used in folk medicine for its anti-ulcer, anti-inflammatory, cicatrizing activities and to treat various pain-related physiological conditions. In the present study, we attempted to verify the possible antinociceptive action of different extracts obtained from the seeds of this plant. Three experimental models...

Author(s): A. Laroubi, L. Farouk, R. Aboufatima, A. Benharref , A. Bagri and A. Chait

February 2009

Toxicological assessment of oral administration of some antisickling agents in rats

  This study investigated the toxicological effects of oral administration of hydroxyurea, tellurite and thiocyanate on some biochemical parameters in rats. The drugs were administered orally to rats daily at their therapeutic dose for 28 days after which some biochemical parameters were measured. All the drugs caused growth depression and significant elevation (P < 0.05) of serum alkaline...

Author(s): Oyewole, O. I. and Malomo, S. O.