African Journal of
Biochemistry Research

  • Abbreviation: Afr. J. Biochem. Res.
  • Language: English
  • ISSN: 1996-0778
  • DOI: 10.5897/AJBR
  • Start Year: 2007
  • Published Articles: 425

Table of Content: May 2009; 3(5)

May 2009

A novel antifungal phenolic compound from Parrotia persica

  Aqueous and methanol extracts of Parrotia persica leaves were assayed for antifungal activity against phytopathogenic Fusarium oxysporum and human pathogenic Candida albicans by poisoned food technique. Both the aqueous and methanol extracts demonstrated significant antifungal activity. Further fractionation of methanol extract guided by antifungal activity resulted in the...

Author(s): M. Ahanjan, M. P. Raghavendra, and K. A. Raveesha

May 2009

Effects of cinnamon on blood glucose and lipids levels in diabetic patients (Type1)

  The present study was designed to investigate the effects of supplementation of cinnamon on blood glucose and lipids levels among type1 diabetics. The samples consisted of 60 subjects with type1 diabetes and the doses of cinnamon were equally administered orally in the form of capsules with breakfast, lunch and dinner. The doses were given for 4 weeks. Blood samples were taken on the starting day of the...

Author(s): Abdul Rahim Al Jamal

May 2009

Salivary amino acids quantification using RP-HPLC during normal menstrual cycle

  The present study was carried out to detect amino acids profile in women saliva in order to establish the qualitative and quantitative differences that might have potential value in detection of ovulation by noninvasive methods. For the collection of sample, the stages of menstrual cycle were decided by the physical and morphological examination of salivary fern pattern. The saliva from various reproductive...

Author(s): S. Alagendran, K. Rameshkumar, K. Palanivelu, N. Puspha, M. Ranjani, N. Arulmozhi and G. Archunan

May 2009

Effects of ivermectin and albendazole on some liver and kidney function indices in rats

  Evaluation of repeated administration of ivermectin and albendazole separately and in combination on some hepatic and renal function indices were examined in albino rats (Rattus novergicus). The experimental animals were randomly divided into four groups: those administered distilled water (control), those administered 0.4 mg/kg bodyweight of ivermectin (Iver), those administered 15 mg/kg body weight...

Author(s): R. O. Arise and S. O. Malomo

May 2009

Effect of 3-hydroxymethyl xylitol on hepatic and renal functional markers and protein levels in streptozotocin-diabetic rats

  Oral administration of 3-hydroxymethyl xylitol at 40 mg/kg body weight to diabetic rats for 45 days resulted in a significant reduction in blood glucose and significant increase in plasma insulin levels. In addition, the diabetic rats had decreased levels of plasma total protein, albumin, globulin and albumin/globulin ratio as compared to control rats. After treatment with 3-hydroxymethyl xylitol and...

Author(s): Govindasamy Chandramohan, Khalid S. Al-Numair and Kodukkur Viswanathan Pugalendi

May 2009

Lipid composition of microsomal fraction of female rat liver at different stages of growth

  It has been reported that lipids are the only macromolecules which display consistency in their pattern of biosynthesis for all living system. In this study, lipid biosynthesis in the liver microsomes of female Sprague-Dawley rats as they aged (3, 7, 12 , 16 and 20 weeks) was studied. The microsomes were isolated by homogenization and centrifugation. The aliquot of the microsomes and soluble enzymes fraction...

Author(s): Chidozie, V. N., Anekwe, G. E., Chukwu, O. O. C., Olabode, O. A., Igweh, A. C. and Adeyanju, O. N.

May 2009

Glutathione S-transferase activity of erythrocyte genotypes HbAA, HbAS and HbSS in male volunteers administered with fansidar and quinine

  In vivo investigations were carried out to ascertain the comparative levels of erythrocyte GST activity between non-malarious and malarious male subjects of HbAA, HbAS and HbSS erythrocyte genotypes, administered with fansidar and quinine. The incubation of human erythrocytes with 1-chloro-2,4-dinitrobenzene (CDNB) resulted in almost quantitative conjugation of glutathione (GSH) to form...

Author(s): P. C. Chikezie, A. A. Uwakwe and C. C. Monago

May 2009

Hepatoprotective potential of crocin and curcumin against iron overload-induced biochemical alterations in rat

  The present study was undertaken to evaluate the possible ameliorating effect of crocin and curcumin on certain biochemical alterations associated with iron overload-induced liver injury in rats. 5 groups of rats were used, a normal control group received daily i.p. injections of saline and 4 groups received daily i.p. injections of ferric nitrilotriacetate (FeNTA) for 8 successive...

Author(s): Shoddy A. EL-Maraghy, Sherine M. Rizk and Maha M. El-Sawalhi

May 2009

Modulation of di- (2- ethylhexyl) phthalate induced hepatic toxicity by Apium graveolens L. seeds extract in rats

  In the present study, the hepatoprotective activity of methanolic extract of Apiumgraveolens L. (celery) seeds was tested against Di-(2- ethylhexyl) phthalate(DEHP) induced hepatotoxicity in rats. Oral administration of DEHP (1000 mg/kg b.wt/day) for 6 weeks in rats caused a significant increase in the levels of serum marker enzymes like serum glutamate oxaloacetate transaminase (SGOT), serum...

Author(s): G. C. Jain, Hemant Pareek, B. S. Khajja, Kusum Jain, S. Jhalani, S. Agarwal and Sameer Sharma

May 2009

Direct ex vivo effects of herbal extracts on serum bilirubin in neonatal blood samples

  Herbal drug therapy is a common practice adopted in traditional and alternative medicine and has been used in the treatment of neonatal jaundice or hyperbilirubinemia from ancient times. This is done with the help of different herbal extracts and using different treatment methods. The knowledge of new possibilities and the fact that herbal drugs have been used in some communities for a long time, clarifies...

Author(s): Seyed Hessamedin Nabavizadeh, Ozair-bin Majid and Amir Anushiravani

May 2009

Toxic effects of aqueous stem bark extract of Cassia sieberiana on some biochemical parameters in rats

  The aqueous extract of Cassia sieberiana stem bark was administered to groups of 4 albino rats (160 ± 10 g) at 0, 20, 60 or 180 mg/kg body weight daily by gavages for six weeks. A 7% decrease in mean body weight gain was observed in the group treated with the highest concentration of the extract (180 mg/kg). Groups treated with the extract showed significant (p < 0.05) increase in serum...

Author(s): W. Obidah, U. A. Sa’ad and A. U. Wurochekke

May 2009

Mechanisms of arsenic toxicity and carcinogenesis

  Industrialization has excessively modified the discharge and distribution of arsenic in the environment through natural and anthropogenic activities. Gastrointestinal tract, Lung and Dermal absorptions account for various adverse effects associated with arsenic toxicity. The knowledge of arsenic biotransformation holds the trivalent species (DMA3+ and MMA3+) accountable for most arsenic toxicity with...

Author(s): Obinaju, Blessing Ebele

May 2009

Effects of sodium ion and water hyacinth extract in the production of Curvularia pallescens in culture media

  An investigation was conducted on the pH, nutritional and cost benefit of the use of different substrates for the production of Curvularia pallescens Boedijn. The growth of the organism was examined at pH range between 5.5 and 8.6 and on different growth media, potato carrot agar (PCA), potato dextrose agar (PDA), sabouraud agar (SA), tap water agar (TWA), water hyacinth agar (WHA) and Czapek-Dox...

Author(s): Okunowo Wahab Oluwanisola and Ogunkanmi Liasu Adebayo

May 2009

Anti anaemic properties of Scoparia dulcis in Trypanosoma brucei infected rabbits

  A major feature of infection with trypanosomes is the development of anaemia. In this study, the effect of Scoparia dulcis (Atiotiousha in Akoko-Edo) onTrypanosoma brucei induced anaemia was investigated in fifteen rabbits divided into three groups of n = 5 over a period of twenty eight days. Changes in Packed cell volume (PCV), Haemoglobin (Hb) concentration, Red blood cell count (RBC), Mean...

Author(s): Orhue N. E. J. and Nwanze E. A. C.

May 2009

Purification and characterization of a laccase from the basidiomycete Funalia trogii (Berk.) isolated in Tanzania

  A lignolytic basidiomycete fungus, Funalia trogii (Berk.), was isolated from decayed wood in coastal Tanzania and cultivated in submerged culture. Initially screened crude enzyme filtrate showed complete rhemazol brilliant blue - R (RBBR) decolorization 2,2’-azino-bis (3-ethylbenzthiazoline)-6-sulfonate and guaiacol oxidation after 7 days of incubation. The fungal...

Author(s): Ferdinandi Patrick, Godliving Mtui, Anthony Manoni Mshandete, Gunnar Johansson and Amelia Kivaisi

May 2009

Effects of curcumin and tetrahydrocurcumin on diabetes induced endothelial dysfunction

  Diabetes-induced endothelial dysfunction has been well recognized for its underlining causes of oxidative stress. Therefore, several studies have worked on testing active antioxidant agents such as vitamin C and E against diabetes induced oxidative stress to preserve endothelial cells. In the present study, we assessed the effects of plant-derived antioxidant, curcumin and its analog, tetrahydrocurcumin (THC)...

Author(s): Natchaya Wongeakin, Pattarin Sridulyakul, Amporn Jariyapongskul, Apichart Suksamrarn and Suthiluk Patumraj