African Journal of
Cellular Pathology

OFFICIAL PUBLICATION OF THE SOCIETY FOR CELLULAR PATHOLOGY SCIENTISTS OF NIGERIA
  • Abbreviation: Afr. J. Cell. Path
  • Language: English
  • ISSN: 2449-0776
  • DOI: 10.5897/AJCPath
  • Start Year: 2013
  • Published Articles: 65

Full Length Research Paper

Histological and histochemical assessements on the effect of ethanol fruit extract of Phoenix dactylifera L. (Date Palm) on cerebral cortex of lead acetate treated wistar rats

Stephen Samuel Lazarus
  • Stephen Samuel Lazarus
  • Department of Human Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, Ahmadu Bello.
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Samuel Sunday Adebisi
  • Samuel Sunday Adebisi
  • Department of Human Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, Ahmadu Bello.
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Yusuf Tanko
  • Yusuf Tanko
  • Department of Human Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, Ahmadu Bello.
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Abel Nosereme Agbon
  • Abel Nosereme Agbon
  • Department of Human Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, Ahmadu Bello.
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Michael Ndomi Budaye
  • Michael Ndomi Budaye
  • Department of Human Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, Ahmadu Bello.
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  •  Received: 03 April 2018
  •  Accepted: 21 May 2018
  •  Published: 30 June 2018

Abstract

This study histologically and histochemically assess the effect of ethanol fruit extract of Phoenix dactylifera L. (EFPD) on the cerebral cortex of lead acetate exposed Wistar rats. Twenty rats were grouped into five groups (A to E, n=4). Group A (control) was administered distilled water (2 ml/kg), while groups B to E were treatment groups. Cerebral damage was induced in rats by the administration of lead acetate (120 mg/kg). Groups B, C, D and E were administered lead acetate (120 mg/kg) for a period of 3 weeks, after which groups C and D were administered EFPD (500 and 1000 mg/kg, respectively) and group E was administered dimercaptosuccinic acid (10 mg/kg) for 2 weeks. All administrations were via oral route, once daily. Microscopic examination of cerebral sections of lead acetate-treated rats revealed histo-architectural alteration; cortical degenerative changes, such as, necrosis, satellitosis, vacuolation and neuronal cytoplasmic shrinkage. However, administration of EFPD remarkably ameliorated lead acetate-induced cortical cerebral degenerative changes in the rats, in a dose dependently manner, as compared to the reference drug dimercaptosuccinic acid. Results suggest that EFPD is a potential therapeutic agent against lead acetate-induced cortical cerebral alterations in Wistar rats.  

Key words: Cerebrum, lead acetate, Phoenix dactylifera L, Wistar rats.