African Journal of
Cellular Pathology

OFFICIAL PUBLICATION OF THE SOCIETY FOR CELLULAR PATHOLOGY SCIENTISTS OF NIGERIA
  • Abbreviation: Afr. J. Cell. Path
  • Language: English
  • ISSN: 2449-0776
  • DOI: 10.5897/AJCPath
  • Start Year: 2013
  • Published Articles: 107

Evaluation of the lethal dose of the methanol extract of rhizophora racemosa leaf using Karber’s method

Angalabiri-Owei BE
  • Angalabiri-Owei BE
  • Department of Pharmacology, Faculty of Basic Medical Sciences, College of Health Sciences, Niger Delta University, Amassoma, Nigeria
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Isirima JC
  • Isirima JC
  • Department of Pharmacology, Faculty of Basic Medical Sciences, College of Health Sciences, University of Port Harcourt, Port Harcourt. Nigeria
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Angalabiri-Owei BE
  • Angalabiri-Owei BE
  • Department of Pharmacology, Faculty of Basic Medical Sciences, College of Health Sciences, Niger Delta University, Amassoma, Nigeria
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Isirima JC
  • Isirima JC
  • epartment of Pharmacology, Faculty of Basic Medical Sciences, College of Health Sciences, University of Port Harcourt, Port Harcourt. Nigeria
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Angalabiri-Owei BE
  • Angalabiri-Owei BE
  • Department of Pharmacology, Faculty of Basic Medical Sciences, College of Health Sciences, Niger Delta University, Amassoma, Nigeria
  • Search for this author on:
  • Google Scholar
Isirima JC
  • Isirima JC
  • Department of Pharmacology, Faculty of Basic Medical Sciences, College of Health Sciences, University of Port Harcourt, Port Harcourt. Nigeria
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  •  Received: 01 May 2014
  •  Published: 31 May 2014

Abstract

Aim: To evaluate the median lethal dose (LD50) of the methanol extract of Rhizophora racemosa leaf commonly used for toothache and dysmenorrhoea in the Niger Delta Area of Nigeria.

Methods: The modified arithmetic Karber’s method by Aliu and Nwude was used. Various doses of the extract were administered to adult albino rats through intraperitoneal route and the LD50 was calculated.

Results: The result revealed that the LD50 of the methanol extract was 1583.33 mg/kg which is within safe level of consumption.

Conclusion: This research therefore provides a scientific evidence that the traditional medicinal use of this plant is safe within the dose limit established.

Keywords: LD50, Rhizophora racemosa, Mangrove plant, Karber’s method, Intraperitoneal.

Copyright © 2024 Author(s) retain the copyright of this article.

This article is published under the terms of the Creative Commons Attribution License 4.0

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