May 2014

Evaluation of the lethal dose of the methanol extract of rhizophora racemosa leaf using Karber’s method

Aim: To evaluate the median lethal dose (LD50) of the methanol extract of Rhizophora racemosa leaf commonly used for toothache and dysmenorrhoea in the Niger Delta Area of Nigeria. Methods: The modified arithmetic Karber’s method by Aliu and Nwude was used. Various doses of the extract were administered to adult albino rats through intraperitoneal route and the LD50 was calculated. Results: The result...

Author(s): Angalabiri-Owei BE, Isirima JC

May 2014

Histomorpohological assessment of the extract of the stalk of sorghum bicolor as a counterstain

Aim: The objective of this study was to investigate the staining ability of the extract of the stalk of Sorghum bicolor as a counterstain on Haematoxylin. Methods: Tissue blocks of trachea, oesophagus and ileum were retrieved from the Autopsy Block Archive of the Department of Pathology, University of Ilorin Teaching Hospital Ilorin. Eight (8) serial sections labeled A to H were made from each block and stained...

Author(s): Omoowo BT, Bankole JK, Muhammed AO, Benard SA, Afolabi OO

May 2014

The effect of Vernonia Amygdalina and Ocimum Gratissimum on Alloxan-induced diabetic rats

Aim: Anti-diabetic evaluation of Vernonia amygdalina and Ocimum gratissimum on alloxan induced diabetic rats was investigated. Methods: Thirty rats were divided into six groups of five per group. The rats were fed with aqueous and ethanolic plant extracts of the plants. Results: On day 2 post induction, fasting blood glucose of all the animals across the groups increased significantly (P<0.05) compared to pre...

Author(s): Adewoga TOS, Sebiomo A, Fagbemi FT

May 2014

TESTICULAR ALTERATION IN OVER DOSAGE OF AZATHIOPRINE: A HISTOLOGICAL AND HISTOCHEMICAL STUDY IN WISTAR RATS

Aim: The use of Azathioprine (AZA) in the prevention of organ rejection during transplantation has been documented for different organs of the body. In this study, we investigated the effects of azathioprine on the integrity of the testis of Wistar rats using histological and histochemical techniques. Methods: Eighteen adult male Wistar rats with mean weight 210±2.65 g were randomly assigned into three...

Author(s): Onanuga IO, Ibrahim RB, Amin A, Omotoso GO