African Journal of
Cellular Pathology

OFFICIAL PUBLICATION OF THE SOCIETY FOR CELLULAR PATHOLOGY SCIENTISTS OF NIGERIA
  • Abbreviation: Afr. J. Cell. Path
  • Language: English
  • ISSN: 2449-0776
  • DOI: 10.5897/AJCPath
  • Start Year: 2013
  • Published Articles: 80

HEMATOLOGICAL EVALUATION OF ABINO RATS ORALLY ADMINISTERED PYRETHROIDS FORMULATION

Iteire AK
  • Iteire AK
  • Department of Anatomy, University of Medical Sciences, Ondo State, Nigeria
  • Google Scholar


  • Article Number - EA360A965706
  • Vol.7(1), pp. 6-10 , July 2016
  •  Received: 23 January 2016
  •  Accepted: 23 June 2016
  •  Published: 31 July 2016

Abstract

Aim: This study was carried out to determine the effect of Mortein on some hematological parameters.

Methods: Fifty adult Albino rats (150- 200g) were acquired from the animal house of the College of Health Sciences, Delta State University Abraka and placed into four groups. Groups 1- 3 contained 15 rats each, while 4 contained 5 rats. Groups 1-3 were further sub-divided into 3 sub-groups of 5 rats each. The rats in Groups 1-3 were treated with 3 different doses of M for 7, 21 and 40 days respectively while Group 4 was given water as placebo. The rats were later sacrificed and blood samples were collected for hematological analysis. The data generated were presented as mean and standard error of mean. Significant differences were obtained by One Way Analysis of Variance at (p ≤ 0.05) with the aid of SPSS version 21.

Results: Significant decrease in total white blood cell count was observed in rats treated with M in dose and time-dependent manner when compared to rats of the control group. There was also a consequent time-dependent significant decrease (p ≤ 0.05) of lymphocyte, significant increase (p ≤ 0.05) of neutrophil and slight increase of monocyte when compared to the control. Subsequently, PCV significantly (p ≤ 0.05) reduced in treated rats compared to the control.

Conclusion: Over exposure to the insecticide, Mortein reduces total white blood cells and packed cell volume.

Keywords: Mortein, Albino Rats, Hematological, Blood, Pyrethroids