African Journal of
Environmental Science and Technology

  • Abbreviation: Afr. J. Environ. Sci. Technol.
  • Language: English
  • ISSN: 1996-0786
  • DOI: 10.5897/AJEST
  • Start Year: 2007
  • Published Articles: 1126

Full Length Research Paper

Studies on the hepatic antioxidant defense system in λ cyhalothrin-induced oxidative stress in fresh water tilapia (Oreochromis mossambicus)

Rekha Parthasarathy* and John Joseph
Department of Zoology, Sacred Heart College, Thevara- Ernakulam Kerala, India
Email: [email protected]

  •  Accepted: 30 May 2011
  •  Published: 31 July 2011



The present study was undertaken to determine the effects of λ cyhalothrin-induced oxidative stress in fresh water tilapia (Oreochromis mossambicus) with respect to changes in the levels of lipid peroxidation [LPO], reduced glutathione [GSH], glutathione-dependent antioxidant enzymes (glutathione peroxidase [GPX] and glutathione-S-transferase [GST]) and antiperoxidative enzymes (catalase [CAT] and superoxide dismutase [SOD]). Significant (P<0.05) elevation in the level of lipid peroxidation was observed in λ cyhalothrin-intoxicated fishes as compared to controls. A concomitant (P<0.05) decline in hepatic antioxidant status was also observed. The results of the present investigation have indicated that the tissue antioxidant defense system is operating at a lower rate despite increased λ cyhalothrin-induced oxidative stress.


Key words: Antioxidant status, λ cyhalothrin, lipid peroxidation, Oreochromis mossambicus, oxidative stress, synthetic pyrethroid