The antigenotoxic action of fennel (Foeniculum vulgare) were assessed using the eye (w/w+) somatic mutation and recombination test (SMART) assay of Drosophila melanogaster. Fennel is used for various medicinal purposes. Methyl methanesulfonate (MMS) was used as the positive control. Fruit extracts of fennel did not show genotoxicity at the doses used. In the co-treatment, a dose-dependent decrease in mutation frequency was observed for this plant. The fennel at 8% (w/v) demonstrated a marked decrease in MMS with an inhibition rate of 41.16%. The results demonstrate that the fennel exerted a significant and potent anti-mutagenic activity in eyes spot of D. melanogaster.
Key words: Drosophila melanogaster, somatic mutation and recombination test (SMART), antigenotoxicity, Foeniculum vulgare, methyl methanesulfonate (MMS).
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