African Journal of
Food Science

  • Abbreviation: Afr. J. Food Sci.
  • Language: English
  • ISSN: 1996-0794
  • DOI: 10.5897/AJFS
  • Start Year: 2007
  • Published Articles: 830

Full Length Research Paper

Tissue distribution and elimination of erythromycin in giant freshwater prawn (Macrobrachium rosenbergii) depletion

N. P. Minh1, T. B. Lam1, N. T. Giao2 and N. C. Quan2
1Department of Food Technology, Ho Chi Minh City University of Technology, 268 Ly Thuong Kiet Street, District 10, Ho Chi Minh City, Vietnam. 2VietNam - Russia Tropical Center, South Branch, 3 3/2 Streets, District 10, HCM City, Vietnam.
Email: [email protected]

  • Article Number - 86D8AD825955
  • Vol.4(9), pp. 578 - 584 , September 2010
  •  Accepted: 10 August 2010
  •  Published: 30 September 2010


Adult giant freshwater prawns (Macrobrachium rosenbergii) were fed with practical diets medicated with erythromycin (50 and 100 mg/ kg shrimp for 7 days), while erythromycin residues in their muscle were determined by LC-MS/MS method through TUV Rheinland Aimex Vietnam Co., Ltd. Interpolation of the study’s data, following European Agency for the Evaluation of Medicinal Products Guidelines, gave a withdrawal time of 976°C-days (°C-day_water temperature-days) or 35 days. Our study provides preliminary data for a more prudent use of erythromycin in giant freshwater prawns, suggesting a possible withdrawal time after treatment. However, medication at a dose of 100 prawn body for 7 days via feed, shows that erythromycin was derived slightly by erythromycin E (2.09 µg/kg) after 1 day of post-treatment. This biotransformation was kept on derivation of erythromycins (erythromycin E: 5.81 µg/kg, erythromycin F: 3.52 µg/kg) at a safe residue on day 23 of post-treatment.


Key words: Giant freshwater prawns, erythromycin, LC-MS/MS, withdrawal time, biotransformation.

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