African Journal of
Food Science

  • Abbreviation: Afr. J. Food Sci.
  • Language: English
  • ISSN: 1996-0794
  • DOI: 10.5897/AJFS
  • Start Year: 2007
  • Published Articles: 976

Full Length Research Paper

Effect of Citrus aurantifolia juice on bodyweight and haematological indices of wistar rats

Ezeigwe Obiajulu Christian
  • Ezeigwe Obiajulu Christian
  • Department of Applied Biochemistry, Faculty of Biosciences, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria.
  • Google Scholar
Okpala Chukwuemeka Obumneme
  • Okpala Chukwuemeka Obumneme
  • Department of Applied Biochemistry, Faculty of Biosciences, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria.
  • Google Scholar
Enemali Michael Okey
  • Enemali Michael Okey
  • Department of Applied Biochemistry, Faculty of Biosciences, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria.
  • Google Scholar
Iloanya Ebele Lauretta
  • Iloanya Ebele Lauretta
  • Department of Applied Biochemistry, Faculty of Biosciences, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria.
  • Google Scholar
Chigbo Chidiebere Malachy
  • Chigbo Chidiebere Malachy
  • Department of Applied Biochemistry, Faculty of Biosciences, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria.
  • Google Scholar
Okeke Chisom Miracle
  • Okeke Chisom Miracle
  • Department of Applied Biochemistry, Faculty of Biosciences, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria.
  • Google Scholar
Okeke Chioma Blessing
  • Okeke Chioma Blessing
  • Department of Applied Biochemistry, Faculty of Biosciences, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria.
  • Google Scholar
Okafor Michael Chinonso
  • Okafor Michael Chinonso
  • Department of Applied Biochemistry, Faculty of Biosciences, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria.
  • Google Scholar


  •  Received: 07 February 2022
  •  Accepted: 20 June 2022
  •  Published: 30 June 2022

References

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Akhtar SS (2013). Evaluation of Cardiovascular Effects of Citrus aurantifolia (Linn.) Fruit. Social Science Research Network: Retrieved from:

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Alaebo PO, Chukwu CN, Nwuke CP, Ezeigwe OC, Ekwunoh PO (2020). Hepatoprotective and Antioxidant Effects of Methanol Extract of Soursop (Annona muricata) Seeds on Alloxan-induced Diabetic Wistar Rats. Nigerian Research Journal of Chemical Sciences 8(2):199-210.

 

Alisa CO, Ezeigwe OC, Ononamadu CJ, Obasi NA, Ezem SN, Okoro JC (2015). Effects of oral administration of aqueous extract of kuding leaves on the weight and packed cell volume (PCV) of wistar albino rats. International Journal of Pharma Sciences 5(3):1050-1055.

 

Amin KA, Nagy MA (2009). Effect of Carnitine and herbal mixture extract on obesity induced by high fat diet in rats. Diabetology and Metabolic Syndrom 1(1):17.
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Aune D, Giovannucci E, Boffetta P, Fadnes LT, Keum N, Norat T, Greenwood DC, Riboli E, Vatten LJ, Tonstad S (2017). Fruit and vegetable intake and the risk of cardiovascular disease, total cancer and all-cause mortality-a systematic review and dose-response meta-analysis of prospective studies. International Journal of Epidemiology 46(3):1029-1056.
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Bagatela BS, Lopes AP, Cabral EC, Perazzo FF, Ifa DR (2015). High-performance thin-layer chromatography/ desorption electrospray ionization mass spectrometry imaging of the crude extract from the peels of Citrus aurantium L. (Rutaceae). Rapid Communications in Mass Spectrometry 29(16):1530-1534.
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Barceloux DG (2008). Citrus Oil and Limonene, in Medical Toxicology of Natural Substances, pp. 635-643, John Wiley and Sons, Incorportated, Hoboken, NJ, USA.

 

Barrientos ELB, Legaspi JT, Paus KGO, Yamzon AR, Castor RM (2020). Effects of citrus sinensis (orange) and lycopersicon esculentum miller (tomato) juices on the hematological parameters of rattus albus (albino rat). European Journal of Molecular and Clinical Medicine 7(2): 4087-4095.

 

Crowe FL (2015). Fruit and vegetable consumption is associated with reduced all cause and cardiovascular mortality. BMJ Evidence-Based Medicine 20(1):14-14.
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Enejoh OS, Ogunyemi IO, Bala MS, Oruene IS, Suleiman MM, Ambali SF (2015). Ethnomedical Importance of Citrus aurantifolia (Christm) Swingle. The Pharma Innovation Journal 4(8):01-06.

 

Eyong EU, Umoh IB, Ebong, PE, Eteng MU, Antai AB, Akoa AO (2004). Heamotoxic effects following ingestion of Nigerian crude oil and crude oil polluted shellfish by rats. Nigerian Journal Physiology Science 19(1-2):1-6.
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Ezeigwe OC, Alisa CO, Ezekwesili-Ofili JO (2018). Effects of Aqueous Extract of Kuding Leaves on Cyanide induced Toxicity and PCV. Academic Journals.

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Ezeigwe OC, Ani ON, Okafor MC (2022). Toxicological studies of Citrus aurantifolia fruit juice in Wistar rats. Asian Journal of Biochemistry, Genetics and Molecular Biology 10(4):38-47.
Crossref

 

Gouegni EF, Abubakar H (2013). Phytochemical, toxicological, biochemical and haematological studies on avocado (Persea americana) in experimental animals. Nigerian Food Journal 31(1):64-69.
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Hamada Y, Nakajima M, Tsuzuki K (2017). Heptamethoxyflavone reduces phosphodiesterase activity and T-cell growth in vitro. International Archives of Allergy and Immunology 174(3-4):113-120.
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Iloanya EL, Nwodo OFC, Ezeigwe OC, Alaebo OP, Enemchukwu NB, Aziagba OB, Opkani IS (2021). Effects of a fraction of the methanol extract of the seeds of Abrus precatorius on malondialdehyde and antioxidant levels of alloxan-induced diabetic rats. Journal of Advances in Biology and Biotechnology 24(1):35-51.
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Kang SR, Park KI, Park HS (2011). Anti-inflammatory effect of flavonoids isolated from Korea Citrus aurantium L. on lipopolysaccharide-induced mouse macrophage RAW 264.7 cells by blocking of nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) signalling pathways. Food Chemistry 129(4):1721-1728.
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Khan H, Amin S (2016). Revival of natural products: utilization of modern technologies. Current Bioactive Compounds 12(2):103-106.
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Khan H, Khan MA, Hussain S, Gaffar R, Ashraf N (2016). In vivo antinociceptive and anticonvulsant activity of extracts of Heliotropium strigosum. Toxicology and Industrial Health 32(5): 860-865.
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Liu L, Shan S, Zhang K, Ning ZQ, Lu XP, Cheng YY (2008). Naringenin and hesperetin, two flavonoids derived from Citrus aurantium up-regulate transcription of adiponectin. Phytotherapy Research 22(10):1400-1403.
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Marya KH, Nabavi SM, Habtemariam H (2018). Anti-diabetic potential of peptides: future prospects as therapeutic agents. Life Sciences 193:153-158.
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Moraes TM, Kushima H, Moleiro FC (2009). Effects of limonene and essential oil from Citrus aurantium on gastric mucosa: role of prostaglandins and gastric mucus secretion. Chemico-Biological Interactions 180(3):499-505.
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Oladejo AA, Osukoya O (2021). Hematological profiles of naturally infected pigs treated with Bridelia ferruginea leaf extracts. Asian Hematology Research Journal 4(2):1-10.

 

Onochie AU, Oli AH, Oli AN, Ezeigwe OC, Nwaka AC, Okani CO, Okam PC, Ihekwereme CP, Okoyeh JN (2020). The pharmacobiochemical effects of ethanol extract of Justicia secunda Vahl leaves in Rattus norvegicus. Journal of Experimental Pharmacology 12:423-437.
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Pellati F, Benvenuti S, Melegari M (2004). High-performance liquid chromatography methods for the analysis of adrenergic amines and flavanones in Citrus aurantium L. var. amara. Phytochemical Analysis 15(4):220-225.
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Rodriguez-Casado A (2016). The health potential of fruits and vegetables phytochemicals: notable examples. Critical Reviews in Food Science and Nutrition 56(7):1097-1107.
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Shen J, Niijima A, Tanida M, Horii Y, Maeda K, Nagai K (2005). Olfactory stimulation with scent of grapefruit oil affects autonomic nerves, lipolysis and appetite in rats. Neuroscientific Letters 380(3):289-294.
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Slavin JL, Lloyd B (2012). Health benefits of fruits and vegetables. Advances in Nutrition 3(4): 506-516.
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Wang X, Ouyang Y, Liu J, Zhu M, Zhao G, Bao W, and Hu FB. (2014). Fruit and vegetable consumption and mortality from all causes, cardiovascular disease, and cancer: systematic review and dose-response meta-analysis of prospective cohort studies. British Medical Journal 349:4490.
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Zhang XL, Xu WF, Chen G, Wang HF, Pei YH (2017). Two new phenolic glycosides isolated from the fruits of Citrus aurantium. Chinese Journal of Natural Medicines 15(1):41-44.
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