Abstract

Multidrug-resistant tuberculosis is involved in multiple haematological manifestations, including anaemia. The objective was to determine the prevalence of anaemia and associated factors in patients with drug-resistant TB. This was a 3-year longitudinal cohort study of patients affected by multidrug-resistant tuberculosis followed up monthly for 9 months by the WHO standardized short treatment regimen in three large multidrug-resistant tuberculosis centres in Conakry. Data were collected using a drug-resistant TB registry form. frequencies were used, means (standard deviation) for data description, and multivariate logistic regression to find factors associated with anaemia. A total of 218 patients were included, mostly men (68.3%), the mean age was 34 years, living mainly in urban areas (77.5%). 23% were seropositive for HIV, 82.6% of patients had already been infected. Anaemia was noted in 71% of patients. In multivariate analysis, HIV-positive patients were more likely to have anaemia (p_value <0.001) as well as vomiting (p_value = 0.049). The results of the biology showed an influence of the leukocyte level (p_value = 0.006) and the platelet count (p_value = 0.043). Anaemia is frequent in multidrug-resistant tuberculosis, serological status, antecedents of antituberculosis treatment, functional and laboratory signs were the factors associated with anaemia.

Key words: Anaemia, TBMR, Guinea.