African Journal of
Medical and Health Sciences

OFFICIAL PUBLICATION OF THE FEDERAL TEACHING HOSPITAL, ABAKALIKI, NIGERIA
  • Abbreviation: Afr. J. Med. Health Sci.
  • Language: English
  • ISSN: 2384-5589
  • DOI: 10.5897/AJMHS
  • Start Year: 2017
  • Published Articles: 17

Full Length Research Paper

Efficacy of intravenous tranexamic acid at reducing blood loss during elective caesarean section in Abakaliki: A double blind randomized placebo controlled trial

Obi V. O.
  • Obi V. O.
  • Department of Obstetrics and Gynaecology, Faculty of Medicine, Federal Teaching Hospital Abakaliki, Nigeria.
  • Google Scholar
Umeora O. U. J.
  • Umeora O. U. J.
  • Department of Obstetrics and Gynaecology, Faculty of Medicine, Federal Teaching Hospital Abakaliki, Nigeria.
  • Google Scholar
Dimejesi I. B. O.
  • Dimejesi I. B. O.
  • Department of Obstetrics and Gynaecology, Faculty of Medicine, Federal Teaching Hospital Abakaliki, Nigeria.
  • Google Scholar
Asiegbu O.
  • Asiegbu O.
  • Department of Obstetrics and Gynaecology, Faculty of Medicine, Federal Teaching Hospital Abakaliki, Nigeria.
  • Google Scholar
Mgbafulu C. C.
  • Mgbafulu C. C.
  • Department of Obstetrics and Gynaecology, Faculty of Medicine, Federal Teaching Hospital Abakaliki, Nigeria.
  • Google Scholar
Ifemelumma C. C.
  • Ifemelumma C. C.
  • Department of Obstetrics and Gynaecology, Faculty of Medicine, Federal Teaching Hospital Abakaliki, Nigeria.
  • Google Scholar
Obi C. N.
  • Obi C. N.
  • Department of Obstetrics and Gynaecology, Faculty of Medicine, Federal Teaching Hospital Abakaliki, Nigeria.
  • Google Scholar


  •  Received: 02 December 2018
  •  Accepted: 15 February 2019
  •  Published: 30 April 2019

References

Abbas AM, Shady NW, Sallam HF (2019). Bilateral uterine artery ligation plus intravenous tranexamic acid during caesarean section for placental previa: a randomized double blind controlled trial. Journal of Gynecology Obstetrics and Human Reproduction 48(2):115-119.
Crossref

 

Ahmed MR, Ahmed WAS, Madny EH, Arafa AM (2015). Said MM. Efficacy of tranexamic acid in decreasing blood loss in elective caesarean delivery. Journal of Maternal-Fetal and Neonatal Medicine 28(9):1014-1018.
Crossref

 

Alam A, Choi S ((2015). Prophylactic Use of Tranexamic Acid for Postpartum Bleeding Outcomes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Transfusion Medicine Reviews e1-11.
Crossref

 

Arulkumaram S (2012). Malpresentation, malposition, Cephalopelvic Disproportion and Obstetric procedures. In: Edmond DK (ed). Dewhurst's Textbook of Obstetrics and Gynaecology. 8th Edition. John Wiley and Sons Ltd. pp. 311-325.
Crossref

 

Bateman BT, Berman MF, Riley LE, Leffert LR (2010). The epidemiology of postpartum hemorrhage in a large, nationwide sample of deliveries. Anesthesia and Analgesia 110:1368-1373.
Crossref

 

Bergholt T, Stenderup JK, Vedsted-Jakobson A, Lenstrup C (2003). Intraoperative surgical complications during caesarean section: an observational study of the incidence and risk factors. Acta Obstetricia et Gynecologica Scandinavica 83(3):251-256.
Crossref

 

Cotter AM, Ness A, Tolosa JE (2001). Prophylactic oxytocin for the third stage of labour. Cochrane Database of Systematic Reviews (4):CD001808.
Crossref

 

Curtin SC, Gregory KD, Korst LM, Uddin SFG (2015). Maternal Morbidity for Vaginal and Cesarean Deliveries, According to Previous Cesarean History: New Data From the Birth Certificate, 2013 National Vital Stat Reports 64(4):e1-14.

 
 

Esike CO, Anozie OB, Onoh RC, Sunday UC, Nwokpor OS, Umeora OU (2016). The prevalence of anemia in pregnancy at booking in Abakaliki, Nigeria. Tropical Journal of Obstetrics and Gynaecology 33:332-336.
Crossref

 

Gai MY, Wu LF, Su QF (2004). Tatsumoto K. Clinical observation of blood loss reduced by tranexamic acid during and after caesarian section: a multi-center, randomized trial. European Journal of Obstetrics and Gynecology and Reproductive Biology 112:154-157.
Crossref

 

Geidam AD, Audu BM, Kawuwa BM, Obed JY (2009). Rising Trend and Indications of Caesarean Section at the University of Maiduguri Teaching Hospital, Nigeria. Annals of African medicine 8(2):127-132.
Crossref

 

Gohel M, Patel P, Gupta A, Desai P (2007). Efficacy of tranexamic acid in decreasing blood loss during and after caesarean section: a randomized case controlled prospective study. The Journal of Obstetrics and Gynecology of India 57:227-230.

 

Guerriero C, Cairns J, Jayaraman S, Roberts I, Perel P, Shakur H (2010). Giving tranexamic acid to reduce surgical bleeding in sub- Saharan Africa: an economic evaluation. Cost Effectiveness and Resource Allocation 8(1):1.
Crossref

 

Gungorduk K, Yildirim G, Asicioglu O, Gungorduk OC, Sudolmus S, Ark C (2011). Efficacy of intravenous tranexamic acid in reducing blood loss after elective cesarean section: a prospective, randomized, double-blind, placebo-controlled study. "American Journal of Perinatology 28:233-240.
Crossref

 

Hellgren M (2003). Hemostasis during normal pregnancy and puerperium. Semin Thromb Hemost 29(2):125-130.
Crossref

 

Incerpi MH. Operative Delivery. In Decherney A.H, Nathan L, Laufer N, Roman A (2013). Diagnosis and Treatment, Obstetrics and Gynecology. Eleventh edition. McGraw-Hill, Company Incorporated pp. 334-348.

 

Kliman HJ (2000). Uteroplacental blood flow: The story of decidualisation, menstruation and trophoblast invasion. The American Journal of Pathology 157:1759-1768.
Crossref

 

Levy JH, Dutton RP, Hemphill JC (2010). Hemostasis summit participants: multi-disciplinary approach to the challenge of hemostasis. Anesthesia and Analgesia 110:354-364.
Crossref

 

Magann EF, Evans S, Hutchinson M, Collins R, Lanneau G, Morrison JC (2005). Postpartum hemorrhage after cesarean delivery: an analysis of risk factors. Southern Medical Journal 98(7):681-685.
Crossref

 

Maged AM, Helal OM, Elsherbini MM, Eid MM, Elkomy RO, Dahab D Elsissy MH (2015). A randomized placebo-controlled trial of preoperative tranexamic acid among women undergoing elective cesarean delivery. International Journal of Gynecology and Obstetrics 131:265-268.
Crossref

 

Movafegh A, Eslamian L and Dorabadi A (2011). Effect of intravenous tranexamic acid administration on blood loss during and after cesarean delivery. International Journal of Gynecology and Obstetrics 115:224-226.
Crossref

 

Novikova N, Hofmeyr GJ (2010). Tranexamic acid for preventing postpartum haemorrhage. Cochrane Database of Systematic Reviews CD007872.
Crossref

 

Novikova N, Hofmeyr GJ, Cluver C (2015). Tranexamic acid for preventing postpartum haemorrhage. Cochrane Database of Systematic Review Issue 6. Art. No: CD007872. 
Crossref

 

Nwobodo EI, Isah AY, Panti A (2011). Elective Caesarean Section in a Tertiary Hospital in Sokoto, North-western Nigeria. Nigerian Medical Journal 52(4):263-265.
Crossref

 

Sadler LC, Davison T, McCowan LM (2000). A randomized controlled trial and meta-analysis of active management of labour. BJOG 107:909-915.
Crossref

 

Shady NW, Sallam HF, Elsayed AH, Abdelkader AM, Ali SS, Alanwar A Abbas AM (2017).The effect of prophylactic oral tranexamic acid plus buccal misoprostol on blood loss after vaginal delivery: a randomized controlled trial. Journal of Maternal-Fetal and Neonatal Medicine 27:1806-1812.

 

Shahid A, Khan A (2013). Tranexamic Acid in Decreasing Blood Loss Duringand after Caesarean Section. Journal of the College of Physicians and Surgeons-Pakistan 23(7):459-462.

 

Shakur H, Elbourne D, Gulmezoglu M, Alfirevic Z, Ronsmans C, Allen E, Roberts I (2010). The WOMAN Trial (World Maternal Antifibrinolytic Trial): tranexamic acid for the treatment of postpartum haemorrhage: an international randomised, double blind placebo controlled trial. Trials 11:40
Crossref

 

Shakur H, Roberts I, Bautista R, Caballero J, Coats T, Dewan Y, El-Sayed H, Gogichaishvili T, Gupta S, Herrera J, Hunt B. CRASH-2 trial collaborators (2010). Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet 376(9734):23-32.
Crossref

 

Ugwu EOV, Obioha KCE, Okezie OA, Ugwu AO (2011). A Five-year Survey of Caesarean Delivery at a Nigerian Tertiary Hospital. Annals of Medical and Health Science Research 1(1):77-83.

 

Yehia AH, Koleib MH, Abdelazim IA, Atik A (2014). Tranexamic acid reduces blood loss during and after cesarean section: A double blinded, randomized, controlled trial Asian Pacific Journal of Reproduction 3(1):53-56.