African Journal of
Pure and Applied Chemistry

  • Abbreviation: Afr. J. Pure Appl. Chem.
  • Language: English
  • ISSN: 1996-0840
  • DOI: 10.5897/AJPAC
  • Start Year: 2007
  • Published Articles: 359

Short Communication

Modification of some organic compounds of pharmaceutical interest

H. R. Lotfy*, H. N. Ssematala and M. Kandawa-Schulz
Department of Chemistry and Biochemistry, Faculty of Science, University of Namibia, Windhoek, Namibia.  
Email: [email protected]

  •  Accepted: 14 November 2011
  •  Published: 30 November 2011


In this article, the modification of the chemical structure of acetaminophen and ibuprofen is described. The esterification, acetaylation and hydrolysis products of acetaminophen and the nitration product of ibuprofen were prepared. The newly synthesized compounds were characterized by IR, 1H NMR and mass spectral analysis. The synthesized products will be tested and evaluated as antimicrobial agents.


Key words: Acetaminophen, ibuprofen, drug, modification.