African Journal of
Pure and Applied Chemistry

  • Abbreviation: Afr. J. Pure Appl. Chem.
  • Language: English
  • ISSN: 1996-0840
  • DOI: 10.5897/AJPAC
  • Start Year: 2007
  • Published Articles: 357

Full Length Research Paper

Synthesis and antibacterial activity of 7-deacetoxy-7α-hydroxygedunin

Okhale S. E
  • Okhale S. E
  • Department of Chemistry, Ahmadu Bello University, Zaria, Nigeria
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Amupitan J. O
  • Amupitan J. O
  • Department of Chemistry, Ahmadu Bello University, Zaria, Nigeria
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Ayo R. G
  • Ayo R. G
  • Department of Chemistry, Ahmadu Bello University, Zaria, Nigeria
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Oladosu P. O
  • Oladosu P. O
  • Department of Microbiology and Biotechnology, National Institute for Pharmaceutical Research and Development, Idu Industrial Area, P. M. B. 21 Garki, Abuja, Nigeria
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Okogun J. I
  • Okogun J. I
  • Pax Herbal International, Ewu, Nigeria
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  •  Accepted: 03 April 2013
  •  Published: 30 April 2013

Abstract

A convenient synthetic route for bioactive 7-deacetoxy-7α-hydroxygedunin was realized by one-step conversion of 7-deacetoxy-7α-hydroxygedunin potassium salt. The 7-deacetoxy-7α-hydroxygedunin was obtained in 88% w/w yield as a fluffy white precipitate by recrystallization from methanol. The 7-deacetoxy-7α-hydroxygedunin and the starting material were evaluated for antibacterial activity against Bacillus subtilisStaphylococcusaureusEscherichia coli, and Klebsiella pneumoniae using the microbroth dilution assay. It was discovered that 7-deacetoxy-7α-hydroxygedunin potassium salt had minimum inhibitory concentration (MIC) of 1000 μg/ml against Kpneumoniae, 2000 μg/ml against S.aureus, and Ecoli. However, Bsubtilis was not susceptible to 7-deacetoxy-7α-hydroxygedunin potassium salt at 2000 μg/ml. Interestingly, 7-deacetoxy-7α-hydroxygedunin had MIC of 2000 µg/ml against Bsubtilis, and Ecoli; and MIC of 1000 µg/ml against Kpneumoniae.

 

Key words: 7-deacetoxy-7α-hydroxygedunin, synthesis, gedunin potassium salt, antibacterial.