African Journal of
Pure and Applied Chemistry

  • Abbreviation: Afr. J. Pure Appl. Chem.
  • Language: English
  • ISSN: 1996-0840
  • DOI: 10.5897/AJPAC
  • Start Year: 2007
  • Published Articles: 357

Short Communication

Analysis of gas-chromatographic method for the determination of ethanol in an 18-F-fluorodeoxyglucose (FDG-18) solution

Santos-Oliveira Ralph1*, Custódio, Cintia de Andrade1, Fusco, Alessandra Silva2 and Fernades, Ricardo Ribeiro Alves2
1Radiopharmaceuticals Division, Nuclear Engineering Institute, Rua Hélio de Almeida No. 75, Ilha do Fundao, Rio de Janeiro, 21.941-906, Brazil. 2Faculty of Pharmacy, Federal University of Rio de Janeiro, Rua Hélio de Almeida No. 75 Ilha do Fundão – Rio de Janeiro, Brazil.
Email: [email protected]

  •  Received: 16 November 2009
  •  Accepted: 14 April 2011
  •  Published: 30 June 2011

Abstract

A gas chromatographic method for determination of ethanol in an fluorodeoxyglucose (FDG)-18 solution was developed. The pre-validation tests were made to test some parameters. Three samples in the concentration of 400, 4000 and 7200 ppm, respectively were analyzed using the novel methodology. The results of the technique were not good. Although the method seems to be capable to identify ethanol in solution, the pre-validation demonstrated a problem in the technique.  The linearity results showed an R2 of 0.66. Further tests must be made to implement this technique in a daily routine.
 
Key words:  Validation, chemical analysis, quality control

Abbreviation

FDG-18, Fluorodeoxyglucose 18; RSD, relative standard deviation; FID, flame ionization detector; RSD, relative standard deviation.