African Journal of
Pure and Applied Chemistry

  • Abbreviation: Afr. J. Pure Appl. Chem.
  • Language: English
  • ISSN: 1996-0840
  • DOI: 10.5897/AJPAC
  • Start Year: 2007
  • Published Articles: 354

Full Length Research Paper

Chemical composition and antimicrobial activity of the seed oil of Entandrophragma angolense (Welw) C.DC.

Abayomi T. Orishadipe1, Nneka N. Ibekwe2, Akinbo A. Adesomoju3 and Joseph I. Okogun2
1Chemistry Advanced Laboratory, Sheda Science and Technology Complex, P. M. B. 186 Garkipo, Sheda, Abuja, Nigeria. 2National Institute for Pharmaceutical Research and Development, P. M. B. 21 Idu Industrial Estate, Idu, Abuja, FCT Nigeria. 3Department of Chemistry, University of Ibadan, Ibadan, Nigeria.
Email: [email protected]

  •  Accepted: 18 October 2012
  •  Published: 30 November 2012


The seed of Entandrophragma angolense yielded 59% oil (w/w) on extraction with n-hexane. Methylation and gas chromatography-mass spectrometry (GC-MS) analysis of the methylated seed oil of E. angolense gave 11-octadecanoic acid methyl ester as major component (43.2%). Other fatty acid methyl esters (FAMEs) detected were hexadecanoic acid methyl ester, ricinoleic acid methyl ester, stearic acid methyl ester and eicosadienoic acid methyl ester. Preliminary antimicrobial evaluation of this seed oil showed activity against Salmonella gallinallum and Klebseilla pneumonia.


Key words: Entandrophragma angolense, octadecanoic, Salmonella gallinallum,Klebseilla pneumonia.