African Journal of
Pure and Applied Chemistry

  • Abbreviation: Afr. J. Pure Appl. Chem.
  • Language: English
  • ISSN: 1996-0840
  • DOI: 10.5897/AJPAC
  • Start Year: 2007
  • Published Articles: 357

Full Length Research Paper

Synthesis of N-alkyl-3- (1H-benzimidazolyl) -2-chloroquinoline derivatives potential candidates against infectious organisms

Gbe Gondo Didier DIOMANDE
  • Gbe Gondo Didier DIOMANDE
  • Laboratoire de Constitution et de Réaction de la Matière – UFR SSMT, Université Félix Houphouët Boigny 22 B.P. 582 Abidjan 22, Cote d'Ivoire.
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Sagne Jacques AKPA
  • Sagne Jacques AKPA
  • Laboratoire de Constitution et de Réaction de la Matière – UFR SSMT, Université Félix Houphouët Boigny 22 B.P. 582 Abidjan 22, Cote d'Ivoire.
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Doumade ZON
  • Doumade ZON
  • Département de Biochimie-Génétique, UFR Sciences Biologiques-Université Gon Coulibaly, BP 1328 Korhogo, Cote d'Ivoire.
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Ané ADJOU
  • Ané ADJOU
  • Laboratoire de Constitution et de Réaction de la Matière – UFR SSMT, Université Félix Houphouët Boigny 22 B.P. 582 Abidjan 22, Cote d'Ivoire.
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  •  Received: 02 December 2020
  •  Accepted: 22 April 2021
  •  Published: 12 July 2021

Abstract

In the search for new drugs possessing the activities we have sought to synthesize new quinoline derivatives which constitute a basic heterocyclic support of some drugs such as quinine, chloroquine marketed under the name Nivaquine®, Mefloquine®, used in the treatment of malaria. The objective of this work is to contribute to the synthesis of new derivatives of quinoline. It consists in introducing heterocycles such as benzimidazole in its 3-position. The introduction of heterocyclics, aryls or alkyls on the pyrrolic nitrogen of benzimidazole, allowed us to obtain compounds 3a-f. The chemical structures of all these compounds were determined by NMR (1H, 13C) and electron impact mass spectrometry.

Key words: Quinoline, benzimidazole, aryls, alkyls.