African Journal of
Pure and Applied Chemistry

  • Abbreviation: Afr. J. Pure Appl. Chem.
  • Language: English
  • ISSN: 1996-0840
  • DOI: 10.5897/AJPAC
  • Start Year: 2007
  • Published Articles: 354

Full Length Research Paper

Quantitative evaluation of the antipsoriatic activity of sausage tree (Kigelia africana)

Folashade O. Oyedeji1* and Olufunsho Samuel Bankole-Ojo2
1Department of Chemistry, University of Ibadan, Ibadan, Oyo State, Nigeria. 2School of Nursing, St. Gerard’s Hospital, Kaduna, Kaduna State, Nigeria.
Email: [email protected]

  •  Accepted: 18 October 2012
  •  Published: 30 November 2012

Abstract

The antipsoriatic effect of methanol and hexane extracts of the stem, bark, leaves and fruit of Kigelia africana (sausage tree) on cell differentiation was evaluated in the modified mouse tail test for psoriasis. Histopathological studies showed that the topical application of K. africana extracts on the tails of male albino mice-induced orthokeratosis in previously parakeratotic areas of the adult albino mouse tail with significant effects on epidermal thickness. The results of our studies showed that the topical application of K. africanaexhibited an important antipsoriatic activity with K. africana stem methanol extracts exhibiting the highest antipsoriatic activity with little irritation potential.

 

Key words: Kigelia africana, psoriasis, mouse tail test, orthokeratosis, parakeratosis, epidermal thickness, irritation potential.