Abstract

Various biological membranes are synthesized from sugars-based compounds. The hydrophobic groups of them made up the amphiphilic properties in the structure of membrane that consisted fatty acids, and long chain alkyl groups. It had established that cholesterol was an integral component and it affects the fluidity of membranes. We prepared the cholesteryl-(3, 4-dihydroxy-5-methoxy-tetrahydro-furan-2-yl)-methanone from reaction of N-methoxy-N-methyl amide as an effective acylating agent, Weinreb amide, with cholesteryl chloride. Spectroscopic methods elucidated the structure of these compounds.

Key words: Cholesterol, Weinreb, membrane, mannose.