African Journal of
Pure and Applied Chemistry

  • Abbreviation: Afr. J. Pure Appl. Chem.
  • Language: English
  • ISSN: 1996-0840
  • DOI: 10.5897/AJPAC
  • Start Year: 2007
  • Published Articles: 357

Full Length Research Paper

Synthesis of cholesteryl-(3,4-dihydroxy-5-methoxy tetrahydro-furan-2-yl) methanone

Soheila Sedaghat
  • Soheila Sedaghat
  • Department of Chemistry, Islamic Azad University, Tehran North branch, 19136-74711, Iran
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  •  Accepted: 15 January 2013
  •  Published: 31 January 2013

Abstract

Various biological membranes are synthesized from sugars-based compounds. The hydrophobic groups of them made up the amphiphilic properties in the structure of membrane that consisted fatty acids, and long chain alkyl groups. It had established that cholesterol was an integral component and it affects the fluidity of membranes. We prepared the cholesteryl-(3, 4-dihydroxy-5-methoxy-tetrahydro-furan-2-yl)-methanone from reaction of N-methoxy-N-methyl amide as an effective acylating agent, Weinreb amide, with cholesteryl chloride. Spectroscopic methods elucidated the structure of these compounds.

 

Key words: Cholesterol, Weinreb, membrane, mannose.