African Journal of
Pure and Applied Chemistry

  • Abbreviation: Afr. J. Pure Appl. Chem.
  • Language: English
  • ISSN: 1996-0840
  • DOI: 10.5897/AJPAC
  • Start Year: 2007
  • Published Articles: 368

Full Length Research Paper

Solvent effect and catalysis in the synthesis of thiosemicarbazone derivatives from ketones and 4’-phenylthiosemicarbazide

Urbain C. Kasséhin
  • Urbain C. Kasséhin
  • Medicinal Chemistry, Louvain Drug Research Institute, Université catholique de Louvain. 73, Bte B1.73.10, Av. E. Mounier B-1200 Bruxelles, Belgique.U.E. Belgium.
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Fernand A. Gbaguidi
  • Fernand A. Gbaguidi
  • Laboratoire de Chimie Pharmaceutique Organique, Ecole de Pharmacie, Faculté des Sciences de la Santé, Université d'Abomey-Calavi, Campus du Champ de Foire, 01 BP 188, Cotonou Benin Republic West Africa.
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Coco N. Kapanda
  • Coco N. Kapanda
  • Medicinal Chemistry, Louvain Drug Research Institute, Université catholique de Louvain. 73, Bte B1.73.10, Av. E. Mounier B-1200 Bruxelles, Belgique.U.E. Belgium
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Christopher R. McCurdy
  • Christopher R. McCurdy
  • Medicinal Chemistry, School of Pharmacy, 419 Faser Hall, P. O. BOX 1848, Oxford, University, Mississipi 386771848, United States.
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Jacques H. Poupaert
  • Jacques H. Poupaert
  • Medicinal Chemistry, Louvain Drug Research Institute, Université catholique de Louvain. 73, Bte B1.73.10, Av. E. Mounier B-1200 Bruxelles, Belgique.U.E. Belgium.
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  •  Received: 13 May 2014
  •  Accepted: 12 August 2014
  •  Published: 31 August 2014

References

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Kasséhin UC, Gbaguidi FA, Kapanda CN, McCurdy C, Bigot AK, Poupaert J (2013). Electronic and steric effects in the control of the anilinium chloride catalyzed condensation reaction between aldones and 4- phenylthiosemicarbazide. Afr. J. Pure Appl. Chem. 7(9):325-329.
 
 
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Palmer JL, Jencks WP (1980). Nonenforced Concerted General-Acid catalysis of the Dehydration Step in Formaldehyde Thiosemicarbazone Formation. J. Am. Chem. Soc. 102:6466-6472.
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Pavan FR, da S Maia PI, Leite SR, Deflon VM, Batista AA, Sato DN, Franzblau SG, Leite CQ (2010). Thiosemicarbazones, semicarbazones, dithiocarbazates and hydrazide/hydrazones: anti-mycobacterium tuberculosis activity and cytotoxicity. Eur. J. Med. Chem. 45:1898-1905.
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Sayer JM, Jencks WP (1973). Mechanism and catalysis of 2-Methyl-3-thiosemicarbazone Formation. A second change in rate-determining step and evidence for a stepwise mechanism for proton transfer in a simple carbonyl addition reaction. J. Am. Chem. Soc. 95:5637-5649.
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Thygesen MB, Munch H, Sauer J, Clo E, Jorgensen MR, Hindsgaul O, Jensen KJ (2010). Nucleophilic catalysis of carbohydrate oxime formation by anilines. J. Org. Chem. 75:1752-1755.
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