The study of reactivity and selectivity of tertiary amines with aryl chlorothionoformates
o-Nitrophenyl chlorothionoformate reacts readily with unhindered tertiary aliphatic amines in only 10 min at room temperature, and gives the dialkylamine salts after treatment of initial thiocarbamate with dimethyl sulfate followed by hydrolysis with water. The ease of cleavage of alkyl groups from tertiary amines with 4-chlorophenyl chlorothionoformate is benzyl > t-butyl > allyl > methyl and using 2, 4,...
Synthesis, characterization, antimicrobial activity and toxicology study of some metal complexes of mixed antibiotics
Mixed ligand metal complexes of ampicillin and chloramphenicol prepared by using Ni(II), Co(II) and Fe(III) metal chloride hexahydrate were reported and characterized based on some physical properties and spectroscopic analysis such as AAS, UV, and IR spectroscopy. The complexes were proposed to have the formulae [ML1L2](Cl)n ( where M= Ni(II), Co(II), Fe(III); L1 =ampicillin, L2 = chloramphenicol , and...