African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2284

Full Length Research Paper

Effect of salidroside on Bcl-2/Bax protein levels in rats with hemisection-induced spinal cord injury

 Ming Wang1, Ning Zhang2, Rili Ji3 and Jing Zhao4*
1Department of Urology, The second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310000, Zhejiang Province, P. R. China. 2Department of Orthopedics, The second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310000, Zhejiang Province, P. R. China. 3TCM pharmacy, Zhaohui Community Health Service Center, Hangzhou 310000, Zhejiang Province, P. R. China. 4Pharmaceutical Institute, Zhejiang Chinese Medical University, Hangzhou 310000, Zhejiang Province, P. R. China.
Email: [email protected]

  •  Accepted: 18 June 2012
  •  Published: 15 July 2012

Abstract

The effect of salidroside on Bcl-2/Bax protein levels in rats with hemisection-induced spinal cord injury (SCI) was studied. The Sprague Dawley (SD) rats were randomly divided into six groups: Sham operation group, SCI model group, methylprednisolone sodium succinate (MPSS) treatment group, salidroside-low dosage treatment group, salidroside-moderate dosage treatment group, and salidroside-high dosage treatment group. The SD rats were hemisected at the spinal cord, at the T8 vertebra to establish SCI model. 24 h after operation, different dosage of salidroside increased and reduced the protein levels. Noticeably, salidroside at the 100 mg/kg dosage exhibited similar effects as MPSS, which has been frequently used for clinical acute SCI. These results suggested that salidroside can significantly inhibit apoptosis in acute SCI.

 

Key words: Salidroside, spinal cord injury (SCI), Bcl-2/Bax, apoptosis.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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