African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2287

Full Length Research Paper

Comparative excretion of vitexin-2"-O-rhamnoside in mice after oral and intravenous administration

Ye An1, Chaoshen Zhang1, Yang Du2, Lin Zhao2, Zhongzhe Cheng2, Wenjie Zhang2, Xixiang Ying2* and Tingguo Kang2
1Department of Pharmacy, the General Hospital of Shenyang Military Region, Shenyang, Liaoning, 110015, China. 2School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, Liaoning, 116600, China.
Email: [email protected]

  •  Accepted: 03 April 2012
  •  Published: 15 July 2012

Abstract

The aim of the present study was to characterize comparative excretion of pure vitexin-2"-O-rhamnoside (VR) in mice following oral and intravenous administration at dose of 30 mg/kg, therefore, a sensitive and specific high-performance liquid chromatography (HPLC) method using vitexin-4"-O-glucoside as internal standard developed and validated for quantitative analysis of VR. The results of elimination of VR in urinary and fecal excretion following oral and intravenous dosing indicated that VR was mainly excreted as prototype for both routes of administration, and biliary and renal excretions are two major ways for the elimination of VR.

 

Key words: Excretion, high-performance liquid chromatography (HPLC), Vitexin-2"-O-rhamnoside.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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