African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2183

Full Length Research Paper

The plerotic effect of Yunnan Baiyao on renal injury after extracorporeal shock wave lithotripsy

Haifeng Yu1, Dapang Rao1 and Ping Duan2*    
1Department of Urology, The Second Affiliated Hospital, Wenzhou Medical College, Wenzhou 325000, P. R. China. 2Department of Gynecology, The Second Affiliated Hospital, Wenzhou Medical College, Wenzhou 325000, P. R. China.    
Email: [email protected]

  •  Accepted: 17 April 2012
  •  Published: 15 May 2012

Abstract

The objective of this study was to explore the protective effect of Yunnan Baiyao, a traditional Chinese herbal remedy, on renal function after extracorporeal shock wave lithotripsy (ESWL).55 patients with renal pelvic stones were randomized to two groups: The control group (n = 25), where the patients were administered with Paishi Chongji (a traditional Chinese herbal granule for removing stones) after ESWL; and the study group (n = 30), where the patients were administered with Paishi Chongji and Yunnan Baiyao after ESWL. Urine microproteins and peripheral venous malondialdehyde (MDA), superoxide dismutase (SOD), endothelin-1 (ET-1) and nitric oxide (NO) were determined before ESWL, and at 24, 72 h and one week after ESWL. Urine, albumin (ALB), immunoglobulin (IgG) and beta-2-microglobulin (β2-MG) levels increased significantly, and urine THP decreased significantly after ESWL. Peripheral ET-1 and MDA at 24 and 72 h after ESWL were significantly lower, while peripheral SOD and NO were significantly higher in the study group than those in the control group (both P < 0.05). In conclusion, Yunnan Baiyao has a definite plerotic effect on renal injury after ESWL and could be spread widely for clinical use.

 

Key words: Yunnan Baiyao, renal injury, extracorporeal shock wave lithotripsy (ESWL).