Abstract

The present study investigated the efficacy of fresh and dried leaves extracts of Rhizophora mucronata in experimental animal models and reveals that the fresh leaf extract showed remarkable improvement in the level of counts of red blood cells (RBC), white blood cells (WBC), platelet count, differential count and the level of hemoglobin and packed cell volume (PCV) and also the level of total protein, albumin, globulin, cholesterol and urea with the exception of a transient rise in total bilurubin, serum glutamic oxaloacetic transaminase (SGOT) and urea, but serum glutamic pyruvic transaminase (SGPT)  rise only in dried leaves extract of R. mucronata. It is also confirmed by the present study that some of the important phytochemical constituents, such as carboxylic acids, flavonoids, proteins and amino acids, steroids and tannin are predominant in fresh leaves than in dried leaf extract. Hence, the extract from fresh leaves of R. mucronata extract dose of 500 mg kg^-1 by oral is safe and non-toxic.

Key words: Rhizophora mucronata, toxicity, hematological parameters, biochemical parameters, mangroves.