African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2195

Full Length Research Paper

Phyto-pharmacological screenings of two Rubiaceae family plants

Nasreen Sultana
  • Nasreen Sultana
  • Department of Pharmacy, Faculty of Science and Engineering, Southern University Bangladesh. Mehedibag-4000, Chittagong, Bangladesh.
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Md. Torequl Islam*
  • Md. Torequl Islam*
  • Department of Pharmacy, Faculty of Science and Engineering, Southern University Bangladesh. Mehedibag-4000, Chittagong, Bangladesh., 2. Department of Biochemistry and Pharmacology, Post-graduation Program in Pharmaceutical Science, Federal University of Piaui, 64.049-550, Teresina, Brazil.
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Marcus Vinicius Oliveira Barros de Alencar
  • Marcus Vinicius Oliveira Barros de Alencar
  • Department of Biochemistry and Pharmacology, Post-graduation Program in Pharmaceutical Science, Federal University of Piaui, 64.049-550, Teresina, Brazil.
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Samara Wanessa Cardoso Silva
  • Samara Wanessa Cardoso Silva
  • Department of Biochemistry and Pharmacology, Post-graduation Program in Pharmaceutical Science, Federal University of Piaui, 64.049-550, Teresina, Brazil.
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Mohi Uddin Chowdhury
  • Mohi Uddin Chowdhury
  • Department of Pharmacy, Faculty of Science and Engineering, Southern University Bangladesh. Mehedibag-4000, Chittagong, Bangladesh.
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Ana Amelia Carvalho Melo-Cavalcante
  • Ana Amelia Carvalho Melo-Cavalcante
  • Department of Biochemistry and Pharmacology, Post-graduation Program in Pharmaceutical Science, Federal University of Piaui, 64.049-550, Teresina, Brazil.
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Rivelilson Mendes de Freitas
  • Rivelilson Mendes de Freitas
  • Department of Biochemistry and Pharmacology, Post-graduation Program in Pharmaceutical Science, Federal University of Piaui, 64.049-550, Teresina, Brazil.
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  •  Received: 06 March 2015
  •  Accepted: 01 July 2015
  •  Published: 22 August 2015

Abstract

In the present study, the ethanol extracts of two plant species namely Hymenodictyon excelsum Roxb. Wall and Mussaenda corymbosa Roxb. from the Rubiaceae family were screened for their phytochemical and pharmacological activities. Phytochemical investigations revealed the presence of important chemical moieties such as alkaloids, glycosides, tannins, falvonoids, saponins, reducing sugars etc. Extracts of M. corymbosa (EMC) showed potent 1,1-diphenyl-1-picrylhydrazyl (DPPH) inhibition at 100 µg/ml. In the antimicrobial activity test by disc diffusion method, the extract of H. excelsum (EHE) showed poor antibacterial activity but good antifungal activity and it strongly inhibited the species, Trichophyton sp. Whereas, EMC at dose of 500 µg/disc showed strong inhibition against Bacillus subtilis, Bacillus megaterium, Salmonella typhi but it was inactive against the test fungi. EHE and EMC showed potent anti-inflammatory, membranstabilizing, analgesic, antipyretic, and moderate amylase inhibition activities. H. excelsum showed stronger central nervous system (CNS) depressing activity on Swiss mice compared to EMC. In conclusion, the plant species may be considered as a medicinal plant and therefore its folk use and further exploitation.

Key words: Investigantions, Hymenodictyon excelsum, Mussaenda corymbosa, pharmacological, phytochemical.