African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2285

Full Length Research Paper

Evaluation of ethanolic extract of Morinda citrifolia Linn for antitumor activity

Gabriela Cavalcante da Silva
  • Gabriela Cavalcante da Silva
  • Laboratório de Farmacologia e Cancerologia Experimental, Centro de Ciências Biológicas, Departamento de Antibióticos, Universidade Federal de Pernambuco – UFPE, Recife-PE, Brazil.
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Gibbelly Cavalcante da Silva
  • Gibbelly Cavalcante da Silva
  • Laboratório de Farmacologia e Cancerologia Experimental, Centro de Ciências Biológicas, Departamento de Antibióticos, Universidade Federal de Pernambuco – UFPE, Recife-PE, Brazil.
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Waneska Alves Pereira da Silva
  • Waneska Alves Pereira da Silva
  • Laboratório de Farmacologia e Cancerologia Experimental, Centro de Ciências Biológicas, Departamento de Antibióticos, Universidade Federal de Pernambuco – UFPE, Recife-PE, Brazil.
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Alisson Macário de Oliveira
  • Alisson Macário de Oliveira
  • Laboratório de Farmacologia e Cancerologia Experimental, Centro de Ciências Biológicas, Departamento de Antibióticos, Universidade Federal de Pernambuco – UFPE, Recife-PE, Brazil.
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Matheus da Silva Mesquita
  • Matheus da Silva Mesquita
  • Laboratório de Farmacologia e Cancerologia Experimental, Centro de Ciências Biológicas, Departamento de Antibióticos, Universidade Federal de Pernambuco – UFPE, Recife-PE, Brazil.
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Maria da Conceição Cavalcanti de Lira
  • Maria da Conceição Cavalcanti de Lira
  • Laboratório de Farmacologia e Cancerologia Experimental, Centro de Ciências Biológicas, Departamento de Antibióticos, Universidade Federal de Pernambuco – UFPE, Recife-PE, Brazil.
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Evandro Valentim da Silva
  • Evandro Valentim da Silva
  • Laboratório de Farmacologia e Cancerologia Experimental, Centro de Ciências Biológicas, Departamento de Antibióticos, Universidade Federal de Pernambuco – UFPE, Recife-PE, Brazil.
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Ivone Antônia de Souza
  • Ivone Antônia de Souza
  • Laboratório de Farmacologia e Cancerologia Experimental, Centro de Ciências Biológicas, Departamento de Antibióticos, Universidade Federal de Pernambuco – UFPE, Recife-PE, Brazil.
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  •  Received: 27 May 2015
  •  Accepted: 10 December 2015
  •  Published: 08 February 2016

Abstract

Given the concern about to the high incidence of cancer and low specificity of available antineoplasic drugs, Morinda citrifolia Linn is a tropical plant species with wide distribution, which had its consumption widely spread both because it is a source of nutrients and its phytotherapic properties as well as for its adaptation. The potential of tumor inhibition was done in vivo against Ehrlich Carcinoma and Sarcoma 180, a sharp reduction of weight of the tumors was obtained in comparison with the control group. The inhibition of tumor growth compared to Ehrlich carcinoma was more prominent in the dose 200 mg/kg/ip with inhibition percentage of 83.91%, on the other hand against Sarcoma 180. The greatest potential inhibition was detected at the dose of 100 mg/kg/ip with a percentage of 85.86%. Measurements of biochemical and hematological markers did not suffer drastic changes. Thus, the ethanol extract of M. citrifolia Linn showed promising antitumor effects towards the used varieties.

Key words: Bioactivity, antitumor, Morinda citrifolia Linn, Sarcoma 180, ehrlich carcinoma.

Copyright © 2024 Author(s) retain the copyright of this article.

This article is published under the terms of the Creative Commons Attribution License 4.0

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