African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2218

Full Length Research Paper

Evaluation of hematological and biochemical activity of Bauhinia strychnifolia Craib leaves ethanol extracts in normal albino rats

Juthaporn Kwansang
  • Juthaporn Kwansang
  • Thai Traditional Medicine College, Rajamangala University of Technology Thanyaburi, 12130, Thailand.
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Watchara Damjuti
  • Watchara Damjuti
  • Thai Traditional Medicine College, Rajamangala University of Technology Thanyaburi, 12130, Thailand.
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Natnaree Siriwon
  • Natnaree Siriwon
  • Thai Traditional Medicine College, Rajamangala University of Technology Thanyaburi, 12130, Thailand.
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  •  Accepted: 09 March 2020
  •  Published: 31 March 2021

Abstract

The aim of this research is to evaluate the hematological and biochemical activity of Bauhinia strychnifolia Craib leaf ethanol extracts in normal albino rats. Thirty-two male and female rats were divided into four groups, each with equal numbers of male (n=4), female (n=4). The control group was administered 1 ml of 10% tween 80. The experimental groups were administered ethanol with concentrations of 125, 250 and 500 mg/kg body weight (bw). After 21 days of treatment, the blood samples were collected for hematological: Red blood cell (RBC), hemoglobin (HGB), hematocrit (HCT), mean corpuscular volume (MCV), white blood cell (WBC), neutrophil (NEU), lymphocyte (LYMPH), monocyte (MONO), eosinophil (EO), basophil (BASO) and biochemical analysis; glucose (GLU), blood urea nitrogen (BUN), creatinine (CREA), cholesterol (CHOL), and triglyceride (TG). The results showed that both male and female rats that received 500 mg/kg bw Craib leaf ethanol extract have increased RBC, HGB, HCT and WBC. The hematological activity in male rats increased significantly (p<0.05) compared to the control group. The biochemical activity in male rats administered with 125 mg/kg bw significantly (p < 0.05) increased BUN, CHOL, and TG compared to the control group. No evidence of abnormalities was observed.

Key words: Bauhinia strychnifolia Craib, hematological, biochemical.