African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2281

Full Length Research Paper

Study of antidiarrheal and anthelmintic activity methanol extract of Commelina benghalensis leaves

Mohammad Shah Hafez Kabir
  • Mohammad Shah Hafez Kabir
  • Department of Pharmacy, International Islamic University Chittagong, Bangladesh.
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Abul Hasanat
  • Abul Hasanat
  • Department of Pharmacy, International Islamic University Chittagong, Bangladesh.
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Tanvir Ahmad Chowdhury
  • Tanvir Ahmad Chowdhury
  • Department of Pharmacy, International Islamic University Chittagong, Bangladesh.
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Mohammad Mamun Ur Rashid*
  • Mohammad Mamun Ur Rashid*
  • Department of Pharmaceutical Sciences, North South University, Dhaka, Bangladesh.
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Mohammed Munawar Hossain
  • Mohammed Munawar Hossain
  • Department of Pharmacy, International Islamic University Chittagong, Bangladesh.
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Shabbir Ahmed
  • Shabbir Ahmed
  • Department of Pharmacy, International Islamic University Chittagong, Bangladesh.
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  •  Received: 21 August 2015
  •  Accepted: 14 October 2015
  •  Published: 29 August 2016

Abstract

The objective of this study was to examine the restorative effects of methanol extract of Commelina benghalensis leaves in antidiarrheal activity in Swiss albino mice model and anthelmintic activity in Tubifex tubifex. Antidiarrheal activity study in Swiss albino mice were divided into four groups. Group I was treated as the control group and received 10 ml/kg of 2% Tween-80 orally; Group II served as a positive control and took standard drug (loperamide) in 5 mg/kg orally; Groups III and IV were the test groups which received the methanol extract of C. benghalensis orally at 200 and 400 mg/kg, respectively. Dependent upon the model comprehensive weight of dry feces, aggregate weight of wet defecation, length of intestinal travel and intestinal weight were gathered. At long last, information were investigated using restricted analysis of variance (ANOVA) took after by Dunnett test. Anthelmintic action on aquarium worm T. tubifex by utilizing three focuses of 10, 5, and 2.5 mg/ml of C. benghalensis movement was assessed by in vitro system. The property of the extract on defecation, intestinal transit and intestinal fluid accumulation (antienteropooling) were assessed in castor oil induced diarrhea. Leaves extract of C. benghalensis at 200 and 400 mg/kg exhibited significant (p<0.05, 0.01 and 0.001) and dose dependent antidiarrheal probable in castor oil induced diarrhea. The diarrhea was inhibited by 27.59 and 55.17 at doses of 200 and 400 mg/kg in that order. The extract  were found to have an antienteropooling in castor oil affected test Swiss albino mice’s by decreasing both weight and volume of intestinal substance, and obviously reducing the intestinal travel similar to that of the standard medication, loperamide (5 mg/kg). Anthelmintic activity of methanol extract C. benghalensis show the time taken for paralysis (12.38, 16.25 and 22.17 min) and time taken for death (21.39, 45.64 and 57.25 min) at doses of 10, 5, and 2.5, respectively. The methanol extract of C. benghalensis demonstrated antidiarrheal effect in Swiss albino mice model and anthelmintic action on aquarium worm T. tubifex. In addition, the extract was discovered to be safe at measurements of 1000, 2000, 3000, and 4000 mg/kg in mice model. The discoveries propose the legitimacy of the much lauded impact of C. benghalensis as antidiarrheal and anthelmintic specialists in expected home grown medication.

Key words: Commelina benghalensis, anti-diarrhea, Swiss albino mice, anthelmintic, Tubifex tubifex.