Abstract

An UV spectrophotometric method using simultaneous equation was developed for the simultaneous determination of ranitidine and itopride in a binary mixture. In the proposed method, the signals were measured at 315.0 and 258.0 nm corresponding to absorbance maxima of ranitidine and itopride hydrochloric acid (HCl) in double distilled water, respectively. Linearity range was observed in the concentration range of 2 to 20 µg/ml for both drugs. Concentration of each drug was obtained by using the absorptivity values calculated for both drugs at two wavelengths, 315.0 and 258.0 nm and solving the simultaneous equation. Developed method was applied to laboratory mixture. The method was validated statistically and recovery study was performed to confirm the accuracy of the method. The method was found to be rapid, simple, accurate and precise.

Key words: Itopride, simultaneous equation, spectrophotometry, ranitidine.