African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2285

Full Length Research Paper

Cubebin and semisynthetic dibenzyl butyrolactone derivatives: Biological activities

Pereira C.C. S. S.
  • Pereira C.C. S. S.
  • Faculty of Pharmaceutical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
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Perazzo, F. F.
  • Perazzo, F. F.
  • Departamento de Ciências Exatas e da Terra, Diadema, University Federal of São Paulo, São Paulo, Brazil.
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Souza G. H. B.
  • Souza G. H. B.
  • Department of Pharmacy, University Federal of Ouro Preto, School of Pharmacy, Ouro Preto, Minas Gerais, Brazil. 4ABC Foundation School of Medicine, Santo André, São Paulo, Brazil.
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Fonseca, F. L. A.
  • Fonseca, F. L. A.
  • Departamento de Ciências Exatas e da Terra, Diadema, University Federal of São Paulo, São Paulo, Brazil.
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Rosa P. C. P
  • Rosa P. C. P
  • Faculty of Pharmaceutical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
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  •  Received: 18 November 2015
  •  Accepted: 17 June 2016
  •  Published: 08 July 2016

Abstract

Lignans are a group of secondary metabolites with a wide variety of chemical structures, formed by coupling two phenylpropanoid units.  Currently, there is great interest in lignan due to the wide range of biological activities this class of compounds has demonstrated. This review describes the biological activities of cubebin and semi-synthetic derivatives, focusing primarily on Piper cubeba and Zantoxyllum naranjillo. The main biological activities reported were: Anti-inflammatory, antitumor, action in erectile dysfunction, trypanocidal, anti-Leishmania and antimicrobial. In this way, it is possible to conclude that cubebin and its derivatives have shown high capacity to become new bioactive molecules obtained by semi-sinthesys, useful to develop medicines for several pathologies, presenting efficacy, toxicology and quality for human use.  

Key words: lignans; cubebin, semisynthetic derivatives; biological activities, Piper cubeba, Piperaceae, Zantoxyllum naranjillo, Rutaceae.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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