African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2165

Full Length Research Paper

Clinical efficacy of Neuronox® botulinum toxin treatment in hemifacial spasm patients

Somsak Tiamkao1*, Supinya Tuntapakul2, Kittisak Sawanyawisuth1 and Suthipun Jitpimolmard1
1Department of Medicine, Faculty of Medicine, Khon Kaen University, Thailand. 2Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Khon Kaen University, Thailand.
Email: [email protected]

  •  Accepted: 01 October 2012
  •  Published: 31 October 2012


Hemifacial spasm (HFS) is a disease causing abnormal movement of the face. Treatment with a botulinum toxin injection is effective. Original botulinum toxin is expensive, particularly in developing countries. We evaluated clinical efficacy and safety of generic botulinum toxin in HFS patients. A 16-week, open labeled, prospective study to evaluate Neuronox® treatment at HFS clinic, Khon Kaen University hospital, Thailand was carried out. Peak improvement (PI), time to PI (TPI), and duration of response period (D) were reported by patients every 4 weeks. In total, 50 HFS patients participated in the study; 30 new and 20 previously diagnosed patients. Two patients did not response to Neuronox® treatment; one in each group. For those who responded to Neuronox® treatment, the mean PI, TPI, and D was 73.44%, 9.44 weeks, and 15 weeks, respectively. The PI, TPI, and D were not statistically different between new and previously diagnosed patients. Ptosis and facial paresis were the common side effects and mostly occurred in the first 4 weeks. Treatment of HFS by generic Neuronox® botulinum toxin is an effective alternative treatment with similar rate of side effects to original botulinum toxin. It may be preferable in countries with limited healthcare resources.


Key words: Hemifacial spasm, Neuronox®, botulinum toxin, efficacy, side effects.

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