African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2148

Full Length Research Paper

Endopleura uchi (Huber) Cuatrec, a medicinal plant with potential anti-inflammatory activity: A review of its phytochemistry and biological activities

Beatriz Martins de Sá Hyacienth1
  • Beatriz Martins de Sá Hyacienth1
  • Programa de Pós-Graduação em Rede de Biodiversidade e Biotecnologia da Amazônia Legal – BIONORTE, Departamento de Ciências Biológicas e da Saúde, Universidade Federal do Amapá, Brasil.
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Brenda Sánchez Ortiz
  • Brenda Sánchez Ortiz
  • Laboratório de Pesquisa em Fármacos, Curso de Farmácia, Departamento de Ciências Biológicas e da Saúde, Universidade Federal do Amapá, Rodovia Juscelino Kubitisheck, km 02, Macapá, Amapá, Brasil.
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Arlindo César Matias Pereira
  • Arlindo César Matias Pereira
  • Laboratório de Pesquisa em Fármacos, Curso de Farmácia, Departamento de Ciências Biológicas e da Saúde, Universidade Federal do Amapá, Rodovia Juscelino Kubitisheck, km 02, Macapá, Amapá, Brasil.
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Danilo Cabral de Sá Hyacienth
  • Danilo Cabral de Sá Hyacienth
  • Laboratório de Pesquisa em Fármacos, Curso de Farmácia, Departamento de Ciências Biológicas e da Saúde, Universidade Federal do Amapá, Rodovia Juscelino Kubitisheck, km 02, Macapá, Amapá, Brasil.
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Josué Arturo Velázquez Moyado
  • Josué Arturo Velázquez Moyado
  • Laboratório de Farmacologia de Productos Naturais, Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Coyoacán, C.P. 04510 Ciudad de México, México.
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Glória Melisa Gonzales Aduanga
  • Glória Melisa Gonzales Aduanga
  • Laboratório de Farmacologia de Productos Naturais, Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Coyoacán, C.P. 04510 Ciudad de México, México.
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Andrés Navarrete
  • Andrés Navarrete
  • Laboratório de Farmacologia de Productos Naturais, Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Coyoacán, C.P. 04510 Ciudad de México, México.
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José Carlos Tavares Carvalho
  • José Carlos Tavares Carvalho
  • Programa de Pós-Graduação em Rede de Biodiversidade e Biotecnologia da Amazônia Legal – BIONORTE, Departamento de Ciências Biológicas e da Saúde, Universidade Federal do Amapá, Brasil.
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  •  Received: 15 January 2019
  •  Accepted: 16 April 2019
  •  Published: 22 April 2019

Abstract

Endopleura uchi (Huber) Cuatrec. is a tree found in the Brazilian Amazon, whose barks are used in folk medicine as an alternative treatment for inflammatory-related diseases. This review, performed using current available international scientific literature, aimed to survey biological activities reported from E. uchi, and describes its phytochemistry. In folk medicine, the barks are used to treat a range of conditions such as intestinal infections, inflammations, diabetes, arthritis, among others; the fruits have some unique nutritional benefits. Phytochemical studies with this plant species indicate the presence of tannins, saponins, and mainly bergenin (a coumarin) in the barks. Among biological activities reported using extracts from the barks are: Inhibition of acetylcholinesterase and butylcholinesterase, bacteriostatic and bactericidal activity, antidiabetic activity through inhibition of α-glucosidase, anti-inflammatory and antioxidant activity. Bergenin, the most abundant molecule, has antimicrobial activity mainly against yeasts and anti-inflammatory activity apparently through mitogen-activated protein kinases (MAPK) and muclear factor kappa B (NF-κB) inhibition; its acetylated derivative acetylbergenin has analgesic and more prominent anti-inflammatory activity.

Key words: Anti-inflammatory, bergenin, Endopleura uchi, phytochemistry.