African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2152

Full Length Research Paper

Efficacy of transurethral resection of prostate in patients of benign prostatic hyperplasia with lower urinary tract symptoms

Shahjahan Ur Rehman
  • Shahjahan Ur Rehman
  • Department of Urology, Lahore General Hospital, Lahore, Pakistan.
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Salman Iftikhar
  • Salman Iftikhar
  • Department of Pharmacology, Rashid Latif Medical and Dental College, Lahore, Pakistan.
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Kamran Zaidi
  • Kamran Zaidi
  • Department of Urology, Lahore General Hospital, Lahore, Pakistan.
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Rao Salman Aziz
  • Rao Salman Aziz
  • Department of Pharmacology, Rashid Latif Medical and Dental College, Lahore, Pakistan.
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Yasir Arfat
  • Yasir Arfat
  • College of Chemistry and Chemical Engineering, Shaanxi University of Science and Technology, Xian, China.
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Muhammad Sohail
  • Muhammad Sohail
  • Department of Urology, Lahore General Hospital, Lahore, Pakistan.
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  •  Received: 20 May 2019
  •  Accepted: 05 July 2019
  •  Published: 31 August 2019

Abstract

Transurethral resection of the prostate (TURP) has been the prime procedure for decenniums to treat benign prostatic hyperplasia (BPH), but is mainly predicated on historic data that lacks utilization of validated measures. It is noteworthy that TURP done nowadays significantly differs from that performed 30 years ago. Men who had undergone TURP between 2013 and 2018 were reviewed. 50 patients presented in the Department of Urology, Lahore General Hospital, Pakistan, with lower urinary tract symptoms (LUTS) due to BPH (without retention) were recruited in the study. Related/required investigations were done and patients were operated for TURP after noting certain parameters. They were advised for follow up at 3 intervals (1st, 4th and 12th week postoperatively) and post-operative parameters were compared with pre-operative ones. International Prostate Symptom Score (IPSS), Quality of Life (QOL) and peak urinary flow rate (Qmax), and Post-Void Residual (PVR) were recorded. Operative details and postoperative complications were documented. Patients were then invited to attend for repeat assessment. Out of 50, 43(86%) patients had severe symptom score and 07 (14%) had moderate symptoms score (pre-operative). Out of total 50, 36 (72%) patients had Qmax less than 10 ml/s and 14 (28%) patients had Qmax between 10 and 15 ml/s as well as Post Micturition Residual Urine (PMRU) more than 50 ml pre-operatively. After 3 months of successful TURP, 49 (98%) patients’ conditions improved and they developed a normal flow rate of more than 20 to 25 ml/s. All the 50 patients remained with a PMRU of less than 50 ml.  There was an improvement in 47 patients and only 3 patients did not improve to their satisfaction. TURP is very effective and still considered a gold standard treatment for BPH with LUTS without retention of urine.

Key words: TURP, BPH, LUTS, PMRU