African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2285

Full Length Research Paper

Hypoglycemic and antioxidant effects of Hibiscus rosa-sinensis L. leaves extract on liver and kidney damage in streptozotocin induced diabetic rats

Lina H. Zaki
  • Lina H. Zaki
  • Botany Department, Woman’s College, Ain Shams University, Cairo, Egypt.
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Samy M. Mohamed
  • Samy M. Mohamed
  • Medicinal and Aromatic Plants Research Department, National Research Centre, 33 El Bohouth P.O. Box 12622, Dokki, Cairo, Egypt.
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Samir A. E. Bashandy
  • Samir A. E. Bashandy
  • Pharmacology Department, National Research Centre, 33 El Bohouth P.O. Box 12622, Dokki, Cairo, Egypt.
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Fatma A. Morsy
  • Fatma A. Morsy
  • Pathology Department, National Research Centre, 33 El Bohouth. P.O. Box 12622, Dokki, Cairo, Egypt.
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Kawther M. Tawfik
  • Kawther M. Tawfik
  • Botany Department, Woman’s College, Ain Shams University, Cairo, Egypt.
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Abdelaaty A. Shahat
  • Abdelaaty A. Shahat
  • Phytochemistry Department, National Research Centre, 33 El Bohouth P.O. Box 12622, Dokki, Cairo, Egypt.
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  •  Received: 06 March 2017
  •  Accepted: 31 March 2017
  •  Published: 08 April 2017

Abstract

Hibiscus is commonly used traditionally for the treatment of some diseases such as hypertension and as antidiabetic herbal medicine. The objective of the present study is to investigate the effect of the oral administration of aqueous methanolic extract of Hibiscus rosa-sinensis leaves (400 mg/Kg) on streptozotocin (STZ) induced diabetic rats and alteration in liver and kidney functions. The treatment of diabetic rats with hibiscus leaves extract reduced levels of plasma glucose, cholesterol, aspartate aminotransferase (AST), alanine aminotransferase (ALT), uric acid and creatinine and hepatic malondialdehyde that was elevated in diabetic rats. Moreover, the Hibiscus leaves extract mitigates the decrease in hepatic superoxide dismutase and plasma protein levels due to STZ injection. The treatment of rats with STZ only results in some pathological effects in liver and kidneys as degeneration in most of hepatocyte and glomeruli. The extract of H. rosa-sinensis leaves reduced the pathological changes. The treatment of diabetic rats with Hibiscus extract was shown to have hepatic and renal protective effects in diabetic rats induced experimentally. Here, two compounds, that is, orientin (Luteolin-8-C-glucoside) and verbascoside (phenylpropanoids glycoside) were isolated from H. rosa-sinsensis. The two compounds were identified by spectral analysis (UV, 1H and 13C-NMR). These results clearly indicate that aqueous leaves extract of H. rosa-sinensis possess antidiabetic and hypolipidemic effects in diabetic rats which may be due to antioxidant properties of the hibiscus extract.

 

Key words: Hibiscus rosa-sinensis, hypoglycemic, antioxidant, orientin, verbascoside.

 

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This article is published under the terms of the Creative Commons Attribution License 4.0

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