Abstract

Diuretics are used for different diseases and are taken without knowing their adverse/side effects. To create awareness, four popular diuretics, Lasix, Spiromide, Aldactone and Conium were investigated for their effect on body. These were experimented over four volunteers with single and double doses. The urine of these volunteers was collected for analysis of sodium and potassium. The obtained results showed that the effect of medicine remained up to 6 to 12 h. In this duration, the sodium excreted value went up for a certain period and then became almost normal and same was true for potassium. The increase in dosage increased the rate of excretion of the cations and also prolonged the time period of their effects. It is concluded that although Lasix, a potential diuretic but its effects over body were also severe in terms of excretion of ions etc. Similarly, Spiromide was also noted to be a reasonably effective diuretic and its effects are totally different from Lasix in terms of excretion of ions and body weight loss. The other two medicines (Aldactone and Conium) did not show much effect upon excretion etc.

Key words: Urine, Lasix, Spiromide, Aldactone, Conium.