African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2205

Full Length Research Paper

Evaluation of the elemental, nutritional and antioxidant properties of Cov-Pla herbal preparations

Ukpe Ajima
  • Ukpe Ajima
  • Plateau State Research Committee on Covid-19 and Other Infectious Diseases, Jos, Plateau State, Nigeria.
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Jacob Adegboyega Kolawole
  • Jacob Adegboyega Kolawole
  • Plateau State Research Committee on Covid-19 and Other Infectious Diseases, Jos, Plateau State, Nigeria.
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Kakjing Dadul Falang
  • Kakjing Dadul Falang
  • Plateau State Research Committee on Covid-19 and Other Infectious Diseases, Jos, Plateau State, Nigeria.
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Bukata Bayero Bukar
  • Bukata Bayero Bukar
  • Plateau State Research Committee on Covid-19 and Other Infectious Diseases, Jos, Plateau State, Nigeria.
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Kennedy Iliya Amagon
  • Kennedy Iliya Amagon
  • Plateau State Research Committee on Covid-19 and Other Infectious Diseases, Jos, Plateau State, Nigeria.
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James Garba Damen
  • James Garba Damen
  • Plateau State Research Committee on Covid-19 and Other Infectious Diseases, Jos, Plateau State, Nigeria.
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Yusuf Amuda Agabi
  • Yusuf Amuda Agabi
  • Plateau State Research Committee on Covid-19 and Other Infectious Diseases, Jos, Plateau State, Nigeria.
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Richard Joseph Kutshik
  • Richard Joseph Kutshik
  • Plateau State Research Committee on Covid-19 and Other Infectious Diseases, Jos, Plateau State, Nigeria.
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Ishaya Yohanna Longdet
  • Ishaya Yohanna Longdet
  • Plateau State Research Committee on Covid-19 and Other Infectious Diseases, Jos, Plateau State, Nigeria.
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Simji Samuel Gomerep
  • Simji Samuel Gomerep
  • Plateau State Research Committee on Covid-19 and Other Infectious Diseases, Jos, Plateau State, Nigeria.
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Ismaila Shittu
  • Ismaila Shittu
  • Plateau State Research Committee on Covid-19 and Other Infectious Diseases, Jos, Plateau State, Nigeria.
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Stephen Daniel Davou
  • Stephen Daniel Davou
  • Plateau State Research Committee on Covid-19 and Other Infectious Diseases, Jos, Plateau State, Nigeria.
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Noel Nen’man Wannang
  • Noel Nen’man Wannang
  • Plateau State Research Committee on Covid-19 and Other Infectious Diseases, Jos, Plateau State, Nigeria.
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  •  Received: 20 September 2020
  •  Accepted: 28 October 2020
  •  Published: 30 November 2020

Abstract

The outbreak of the Covid-19 pandemic has had a dramatic effect on human existence and still shows no sign of abating. Scientists worldwide are therefore working assiduously to get new drug treatments to help mitigate the crisis. Some of those efforts involve research to obtain Covid-19 treatments from natural sources. The present study is aimed at evaluating the elemental, nutritional and antioxidant properties of Cov-Pla1, Cov-Pla2, Cov-Pla3 and PlaBoost herbal preparations. Elemental analysis was carried out using AAS after acid digestion of the samples. Proximate analysis of the formulations was done using the official AOAC methods while the antioxidant assay was carried out using the DPPH free radical scavenging method. The results of the study showed that the concentration of the heavy metals in all the samples were within acceptable regulatory limits. Proximate analysis revealed that the suspensions had protein content between 1.52-1.68 % and carbohydrate content of 0.79 – 1.08 % with low content of fat, crude fibre and ash. The formulations were found to be free of microbial contamination and stable for thirty days. Antioxidant evaluation revealed that Cov-Pla3 had the strongest free radical scavenging capacity with IC50 of 27.29 µg/mL while PlaBoost had the least (IC50: 251 µg/mL). The result of the study indicates that the formulations are free of metallic and microbial contaminants. In addition, proximate analysis has established some diagnostic parameters which will aid future authentication and purity assessment of the formulations. The formulations were all found to possess considerable antioxidant activity which will provide collateral benefit in relieving oxidative stress associated with Covid-19 infection. 

Key words: Covid-19, heavy metals, trace elements, proximate analysis, antioxidant.