Abstract

The antidiabetic effect of water extract of Rosmarinus officinalis was studied in streptozotocin (STZ)-induced diabetes in rats. The efficacy of the extract was also evaluated for protective effects on renal functions and histology in diabetic rats. Oral administration of extract to diabetic rats (200 mg/kg body weight per day for a period of 21 days) produced significant (P <0.001) fall in fasting blood glucose (FBG). Treatment with the extract showed significant improvement in body weight and serum insulin and C-peptide when compared with diabetic control. Also, the extract improved the kidney function and reduced lesions associated with STZ induced diabetes. Thus, our study indicates that the water extract of rosemary (200 mg/kg) exhibits protective effect on these organs, significantly improves the homeostasis of glucose and proves its potentials as an antidiabetic agent. The results of this study serve as valuable data for health professionals in proper menu planning for diabetes mellitus.

Key words: Diabetes mellitus, rosemary, streptozotocin, medicinal plant.