African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2288

Full Length Research Paper

Anti-inflammatory activity of methanolic extract of Eclipta prostrata L (Astearaceae)

G. Arunachalam1*, N. Subramanian2, G. P. Pazhani3 and V. Ravichandran4
1PGP College of Pharmaceutical Science and Research Institute, NH-7, Namakkal - Karur Main Road, Namakkal – 637207, Tamilnadu, India. 2Bharathidasan Institute of Technology, Anna University Tiruchrappalli, Tiruchirappalli - 620 024, Tamilnadu, India. 3KRS Pallavan College of Pharmacy, Mannur - 602 105, Tamilnadu, India. 4Vels College of Pharmacy, Chennai- 600 035, Tamilnadu, India.
Email: [email protected]

  •  Accepted: 17 February 2009
  •  Published: 31 March 2009

Abstract

The methanol extract of leaves of Eclipta prostrata Linn was investigated for anti-inflammatory activity in albino Wistar rats. The methanolic extract administered by the oral route at a concentration of 100 and 200 mgkg-1 showed the significant dose dependent anti-inflammatory activity in carrageenin and egg white induced hind paw oedema in rats. Anti-inflammatory activity of the tested extract was comparable with that of the standard drug indomethacin (10 mgkg-1) and cyproheptadine (8 mgkg-1). The results lend support to the traditional use of E. prostrata in the treatment of inflammatory diseases.

 

Key words: Eclipta prostrate, methanolic extract, albino Wistar rats, anti-inflammatory activity.

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