African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2286

Full Length Research Paper

Baccharis dracunculifolia with high levels of phenol compounds reduces blood glucose in healthy human

Tauana Aparecida de Oliveira
  • Tauana Aparecida de Oliveira
  • Department of Physical Education, Midwest State University of Parana, Irati, PR, Brazil
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Renan Garcia Michel
  • Renan Garcia Michel
  • Departament of Chemistry, Federal Technology University of Paraná, Pato Branco – PR, Brazil
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André Luiz Snak
  • André Luiz Snak
  • Departament of Chemistry, Federal Technology University of Paraná, Pato Branco – PR, Brazil
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Ricardo Aparecido Pereira
  • Ricardo Aparecido Pereira
  • Department of Biomedicine, Faculty Campo Real, Guarapuava, PR, Brazil
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Luiz Augusto da Silva
  • Luiz Augusto da Silva
  • Department of Physical Education, Midwest State University of Parana, Irati, PR, Brazil
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Francini Y. Kagimura
  • Francini Y. Kagimura
  • Departament of Chemistry, Federal Technology University of Paraná, Pato Branco – PR, Brazil
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Mário A.A da Cunha
  • Mário A.A da Cunha
  • Departament of Chemistry, Federal Technology University of Paraná, Pato Branco – PR, Brazil
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Carlos Ricardo Maneck Malfatti*
  • Carlos Ricardo Maneck Malfatti*
  • Departament of Chemistry, Federal Technology University of Paraná, Pato Branco – PR, Brazil
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  •  Received: 25 July 2013
  •  Accepted: 16 June 2014
  •  Published: 29 June 2014

Abstract

The present study aimed to analyze the amount of total phenolics compounds in the extract Baccharis dracunculifolia and evaluate glycemia in healthy humans. The study group consisted of 16 healthy individuals, aged 21±1.4 years. The cardiovascular parameters of blood pressure, heart rate and blood glucose was analyzed before and after treatment with or without B. dracunculifolia (20 mg/kg). B. dracunculifolia intake did not lead to significant changes in the cardiovascular variables, but, its ingestion reduced blood glucose levels in 25% (control group: 99 mg/dL and treated Group: 68 mg/dL, P<0.05). In the extract of B. dracunculifolia was identified hight levels of phenolic compounds (methanol extract: 46.2±0.4 mg GAE/L; acetate extract: 70.5±0.5 mg GAE/L; etanol extract: 30.3±0.21 mg GAE/L), as well as an efficient capacity for blood glucose reduction after oral intake.

 

Key words: Blood glucose, phenolic compounds, essential oils, medicinal plants.

Abbreviation

CG, Control group; TG, treatment group; BG, blood glucose; SBP, systolic blood pressure; DBP, diastolic blood pressure; HR, heart rate.

Copyright © 2024 Author(s) retain the copyright of this article.

This article is published under the terms of the Creative Commons Attribution License 4.0

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