African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2195

Full Length Research Paper

In vitro enzyme inhibition activities of Myrtus communis L.

Seema Begum1, Mumtaz Ali1, Husna Gul1, Waqar Ahmad2, Sultan Alam1, Momin Khan3, Mir Azam Khan2 and Manzoor Ahmad1,4
1Department of Chemistry, University of Malakand, Chakdara, Dir (L), Khyber Pukhtoonkhwa, Pakistan. 2Department of Pharmacy, University of Malakand, Chakdara, Dir (L), Khyber Pukhtoonkhwa, Pakistan. 3Saidu Group of Teaching Hospital, Saidu Sharif, Swat, Khyber Pukhtoonkhwa, Pakistan. 4Swaziland Institute for Research in Traditional Medicine: Medicinal and Indigenous Food Plants, University of Swaziland, Private Bag 4, Kwaluseni, Swaziland.
Email: [email protected]

  •  Accepted: 28 March 2012
  •  Published: 15 April 2012

Abstract

The crude methanolic extract and chloroform, ethyl acetate and n-butanol fractions of Myrtus communis L. were examined as inhibitors of acetylcholinesterase, butyrylcholinesterase and lipoxygenase. A significant enzyme inhib ition activity (81 to 91%) was shown by the crude methanolic extract and its fractions against acetylcholinesterase, while high to outstanding enzyme inhibitory activity (72.5 to 99%) was shown against butyrylcholinesterase. The crude methanolic extract and its various fractions also demonstrated significant activity (79 to 94.5%) against lipoxygenase.

 

Key words:    Myrtus communis L., acetylcholinesterase, butyrylcholinesterase, lipoxygenase, inhibition.