African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2288

Full Length Research Paper

Potential hepatoprotective effects of vitamin E and selenium on hepatotoxicity induced by malathion in rats

Gaber El-Desoky1,2*, Mohammed Abdelreheem3,4, Abdulaziz AL-Othman5, Zeid ALOthman1, Mohamed Mahmoud6,7 and Kareem Yusuf1
1Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia. 2Department of Biochemistry, College of Agriculture, Cairo University, Cairo, Egypt. 3Department of Biochemistry, College of Agriculture, Ain Shams University, Cairo, Egypt. 4Research Center, College of Science, King Saud University, Riyadh, Saudi Arabia. 5Department of Community Health Sciences, College of Applied Medical Science, King Saud University, Riyadh, Saudi Arabia. 6Department of Human Nutrition, National Research Center, Dokki, Cairo, Egypt. 7Deanship of Scientific Research, King Saud University, Riyadh, Saudi Arabia.
Email: [email protected]

  •  Accepted: 07 March 2012
  •  Published: 22 March 2012

Abstract

The aim of this present study was to analyze the hepatotoxic effect of malathion in adult male rats and evaluate the possible hepatoprotective effect of vitamin E and/or selenium. Oral administration of malathion for 45 days significantly induced marked hepatic injury as revealed by increased activity of the plasma enzymes (alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH) and gamma-glutamyl transferaseGGT). Oral administration of vitamin E and selenium in combination with malathion exhibited a significant protective effect by lowering the elevated plasma levels of the previous enzymes. Light microscopic investigation revealed that malathion exposure was associated with necrosis of hepatocytes, marked changes of liver tissues in the form of dilated veins, hemorrhagic spots and some degenerative signs of hepatocytes. Co-administration of vitamin E and selenium with malathion to rats showed mild histopathological changes. Thus, it appears that vitamin E and/or selenium ameliorate malathion hepatotoxicity but are not completely protective.

 

Key words: Malathion, rats enzymes, selenium, vitamin E.

Copyright © 2024 Author(s) retain the copyright of this article.

This article is published under the terms of the Creative Commons Attribution License 4.0

Back to Vol. 6 No. 11
Back to articles
  • Articles on Google by:
SUBSCRIBE TO RSS
SUBMIT MANUSCRIPT
CONFERENCES