Full Length Research Paper
Abstract
An increasing demand for natural additives has drawn more interest from consumers due to their relatively safe and wide acceptance. The present work examines the potential of different solvent system of Clinacanthus nutans Lindau leaves as a source of natural antioxidant. We also screened for its phytochemical constituents and cytotoxicity toward breast cancer cell. In vitro antioxidant activity of the n-hexane, dichloromethane, ethyl acetate, and ethanol extracts were assessed via 1,1-diphenyl-picrylhydrazyl (DPPH) radical scavenging activity, oxygen radical absorbance capacity and ß-carotene bleaching activity assays, whereas the cytotoxic effect was tested on tumorigenic breast cancer estrogen positive cell (MCF-7) and normal fibroblast cell (3T3) using the tetrazolium assay. Liquid chromatography mass spectrometry equipped with an electrospray ionization source liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-
Key words: Cytotoxicity, polyphenols, polyunsaturated fatty acid (PUFA), Sabah snake grass, anticancer.
Copyright © 2024 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0