African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2214

Full Length Research Paper

Evaluation of anti-ulcer and antimicrobial effects of Verbena hastata leaf extract

Akuodor G. C.1*, Akpan J. L.2, Ezeunala Mercy N.3, Ajoku Gloria A.3, Essien A. D.1, Megwas A. U.4, Okoroafor Dorcas O.5, Iwuanyanwu T. C.6 and Osunkwo U. A.6
1Department of Pharmacology, College of Medical Sciences, University of Calabar, Nigeria. 2Department of Pharmacology and Therapeutics, Faculty of Clinical Medicine, Ebonyi State University, Abakaliki, Nigeria. 3Department Microbiology, Human Virology and Biotechnology, National Institute for Pharmaceutical Research and Development (NIPRD), Garki, Abuja, Nigeria. 4Department of Optometry, Imo State University, Nigeria. 5Department of Pharmacognosy and Phytotherapy, Faculty of Pharmaceutical Sciences, University of Port Harcourt, Nigeria. 6Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development (NIPRD), Garki, Abuja, Nigeria.
Email: [email protected]

  •  Accepted: 14 April 2011
  •  Published: 22 March 2012


The ulcer protective and antimicrobial effects of the ethanolic leaf extract of Verbena hastata, a popular herbal traditional medicine in southern Nigeria, were assessed using ethanol and indomethacine induced gastric ulcer in rats and against some disease causing microorganisms, respectively. The extract (100-400 mg/kg, p.o) exerted ulcer-protective activities against ethanol and indomethacine-induced ulceration in rats with maximum anti-ulcer effect observed at 400 mg/kg. In addition, V. hastata leaf extract (2.00 mg/ml) showed absence of antimicrobial effects against all the tested organisms. The oral LD50 values obtained were greater than 5000 mg/kg in mice. The results clearly indicate that V. hastataleaf extract possesses potent ulcer protective properties. It might be a useful contribution to highlight the mechanism of action of this plant as anti-ulcer agent.


Key words: Antimicrobial, Verbena hastata, antiulcer agent, traditional medicine.