African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2159

Review

Chamomile: An ancient pain remedy and a modern gout relief - A hypothesis

Hamed Ghavimi1*, Ali Shayanfar2, Sanaz Hamedeyazdan3, Afshin Shiva4, Afagh Garjani5
1Drug Applied Research Center, Department of Pharmacology and Toxicology, Faculty of pharmacy Tabriz University of Medical Sciences, Tabriz, Iran. 2Liver and Gastrointestinal Diseases Research Center, Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran. 3Biotechnology Research Center and Faculty of Pharmacy Tabriz University of Medical Sciences, Tabriz, Iran. 4Department of Clinical Pharmacy, Faculty of Pharmacy, Pharmaceutical Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran. 5Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Email: [email protected] or [email protected]

  •  Accepted: 02 August 2011
  •  Published: 29 February 2012

Abstract

Matricaria chamomilla (MC) is a well-known medicinal plant. In the present paper, the researchers intended to focus on the possible anti-inflammatory pharmacological mechanisms of MC preparations in the treatment of gouty arthritis and the constituents of MC responsible for its effects. The medicinal preparations of MC are composed of several classes of biologically active compounds with an inhibitory effect on inflammation including essential oils and flavonoidsApigenin, quercetin and luteolin are flavonoids, which exhibit their anti-inflammatory effects via different mechanisms. Apigenin exhibits anti-inflammatory activity via inhibition of proinflammatory cytokines production. Luteolin suppresses production of nitric oxide (NO), prostaglandin E2 and expression of inducible NO synthase (iNOS) and cyclooxygenase-2 – which are all associated with inflammatory responses. In addition, Luteolin along with quercetin, inhibit xanthine oxidase (XO) enzyme. There are also additional components of theMC preparations which play a role in its anti-inflammatory action via other pathways. The mentioned mechanisms are in accordance with the authors’s concept that MC can alleviate inflammation in gouty arthritis.

 

Key words: Matricaria chamomilla, gout, inflammation, essential oils, flavonoids.

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